FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2284196610> ?p ?o ?g. }

• W2284196610 endingPage "461" @default.
• W2284196610 startingPage "449" @default.
• W2284196610 abstract "FABPs (fatty-acid-binding proteins) are a family of low-molecular-mass intracellular lipid-binding proteins consisting of ten isoforms. FABPs are involved in binding and storing hydrophobic ligands such as long-chain fatty acids, as well as transporting these ligands to the appropriate compartments in the cell. FABP5 is overexpressed in multiple types of tumours. Furthermore, up-regulation of FABP5 is strongly associated with poor survival in triple-negative breast cancer. However, the mechanisms underlying the specific up-regulation of the FABP5 gene in these cancers remain poorly characterized. In the present study, we determined that FABP5 has a typical CpG island around its promoter region. The DNA methylation status of the CpG island in the FABP5 promoter of benign prostate cells (PNT2), prostate cancer cells (PC-3, DU-145, 22Rv1 and LNCaP) and human normal or tumour tissue was assessed by bisulfite sequencing analysis, and then confirmed by COBRA (combined bisulfite restriction analysis) and qAMP (quantitative analysis of DNA methylation using real-time PCR). These results demonstrated that overexpression of FABP5 in prostate cancer cells can be attributed to hypomethylation of the CpG island in its promoter region, along with up-regulation of the direct trans-acting factors Sp1 (specificity protein 1) and c-Myc. Together, these mechanisms result in the transcriptional activation of FABP5 expression during human prostate carcinogenesis. Importantly, silencing of Sp1, c-Myc or FABP5 expression led to a significant decrease in cell proliferation, indicating that up-regulation of FABP5 expression by Sp1 and c-Myc is critical for the proliferation of prostate cancer cells." @default.
• W2284196610 created "2016-06-24" @default.
• W2284196610 creator A5033571968 @default.
• W2284196610 creator A5052192528 @default.
• W2284196610 creator A5061850393 @default.
• W2284196610 creator A5076546588 @default.
• W2284196610 creator A5081702016 @default.
• W2284196610 creator A5083706661 @default.
• W2284196610 date "2016-02-09" @default.
• W2284196610 modified "2023-10-10" @default.
• W2284196610 title "The cancer-promoting gene fatty acid-binding protein 5 (<i>FABP5</i>) is epigenetically regulated during human prostate carcinogenesis" @default.
• W2284196610 cites W1484293540 @default.
• W2284196610 cites W1484870202 @default.
• W2284196610 cites W1556697438 @default.
• W2284196610 cites W1562101563 @default.
• W2284196610 cites W1572687140 @default.
• W2284196610 cites W159260871 @default.
• W2284196610 cites W1840670308 @default.
• W2284196610 cites W1958280850 @default.
• W2284196610 cites W1963927869 @default.
• W2284196610 cites W1972168184 @default.
• W2284196610 cites W1976236908 @default.
• W2284196610 cites W1979273476 @default.
• W2284196610 cites W1980273804 @default.
• W2284196610 cites W1980568044 @default.
• W2284196610 cites W1985053389 @default.
• W2284196610 cites W1986484264 @default.
• W2284196610 cites W1987557775 @default.
• W2284196610 cites W1988117658 @default.
• W2284196610 cites W1992980803 @default.
• W2284196610 cites W2010397777 @default.
• W2284196610 cites W2011455390 @default.
• W2284196610 cites W2015787260 @default.
• W2284196610 cites W2019732936 @default.
• W2284196610 cites W2021536610 @default.
• W2284196610 cites W2033893825 @default.
• W2284196610 cites W2034269086 @default.
• W2284196610 cites W2034482399 @default.
• W2284196610 cites W2040474954 @default.
• W2284196610 cites W2040605299 @default.
• W2284196610 cites W2051025382 @default.
• W2284196610 cites W2053856666 @default.
• W2284196610 cites W2058596530 @default.
• W2284196610 cites W2059206291 @default.
• W2284196610 cites W2062348957 @default.
• W2284196610 cites W2066178035 @default.
• W2284196610 cites W2066941077 @default.
• W2284196610 cites W2073463418 @default.
• W2284196610 cites W2074469807 @default.
• W2284196610 cites W2077810304 @default.
• W2284196610 cites W2078713912 @default.
• W2284196610 cites W2079474262 @default.
• W2284196610 cites W2080709087 @default.
• W2284196610 cites W2085293170 @default.
• W2284196610 cites W2086072473 @default.
• W2284196610 cites W2097778167 @default.
• W2284196610 cites W2097851896 @default.
• W2284196610 cites W2099343472 @default.
• W2284196610 cites W2101904615 @default.
• W2284196610 cites W2117692326 @default.
• W2284196610 cites W2123032740 @default.
• W2284196610 cites W2135798683 @default.
• W2284196610 cites W2136423761 @default.
• W2284196610 cites W2138015614 @default.
• W2284196610 cites W2138178697 @default.
• W2284196610 cites W2138914508 @default.
• W2284196610 cites W2143550151 @default.
• W2284196610 cites W2148794649 @default.
• W2284196610 cites W2149790281 @default.
• W2284196610 cites W2150169404 @default.
• W2284196610 cites W2150733697 @default.
• W2284196610 cites W2157230165 @default.
• W2284196610 cites W2161600258 @default.
• W2284196610 cites W2167142486 @default.
• W2284196610 cites W2170639840 @default.
• W2284196610 doi "https://doi.org/10.1042/bj20150926" @default.
• W2284196610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26614767" @default.
• W2284196610 hasPublicationYear "2016" @default.
• W2284196610 type Work @default.
• W2284196610 sameAs 2284196610 @default.
• W2284196610 citedByCount "50" @default.
• W2284196610 countsByYear W22841966102016 @default.
• W2284196610 countsByYear W22841966102017 @default.
• W2284196610 countsByYear W22841966102018 @default.
• W2284196610 countsByYear W22841966102019 @default.
• W2284196610 countsByYear W22841966102020 @default.
• W2284196610 countsByYear W22841966102021 @default.
• W2284196610 countsByYear W22841966102022 @default.
• W2284196610 countsByYear W22841966102023 @default.
• W2284196610 crossrefType "journal-article" @default.
• W2284196610 hasAuthorship W2284196610A5033571968 @default.
• W2284196610 hasAuthorship W2284196610A5052192528 @default.
• W2284196610 hasAuthorship W2284196610A5061850393 @default.
• W2284196610 hasAuthorship W2284196610A5076546588 @default.
• W2284196610 hasAuthorship W2284196610A5081702016 @default.
• W2284196610 hasAuthorship W2284196610A5083706661 @default.
• W2284196610 hasConcept C104317684 @default.
• W2284196610 hasConcept C119056186 @default.

• next