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- W2284220156 abstract "/sup 111/In oxine in vitro labeled red cells were evaluated in rabbits for the ability to detect gastrointestinal (Gl) bleeding. A mean labeling efficiency of 81% (+- 15.5%) was achieved. Biodistribution and translocation data demonstrated 81% of the activity within the blood pool at four hours after intravenous injection, falling to 29% by 72 hours. Peak urine excretion occurred after 60 to 150 minutes. Normal Gl excretion was less than 1% over 72 hours. Simulated lower Gl bleeding was imaged at 4, 12, and 72 hours, and amounts as small as 2 ml (1% blood volume) were seen. In rabbits the total body dose of injected /sup 111/In is 0.15 mGy/MBq (0.56 rad/mCi), and the critical organ is the spleen, which received 0.49 mGy/MBq (1.82 rad/mCi). /sup 111/In oxine labeled red cells provide a sustained blood pool label wthout significant accumulation in the Gl tract, and may have a potential use in the detection of intermittent Gl bleeding in humans." @default.
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- W2284220156 date "1980-05-01" @default.
- W2284220156 modified "2023-09-24" @default.
- W2284220156 title "/sup 111/In oxine labeled red cells for detection of simulated lower gastrointestinal bleeding in an animal model. [Rabbits]" @default.
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