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- W2284227675 abstract "To prevent the attachment of bacteria to implant surfaces, the 1D zinc oxide nanowire-coating has been successfully developed on material surfaces by using a custom-made hydrothermal approach. The chemical nature, surface topography and wettability of spike-like 1D ZnO nanowire-coating are comprehensively investigated. The anti-adhesive and antimicrobial properties of 1D nanowire-coating are tested against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli by using in vitro live/dead staining and scanning electron microscopy. We find that the adhesion of bacteria can be reduced via the special spike-like topography and that the release of Zn(2+) ions can help suppress the growth of attached bacteria. Furthermore, the antimicrobial effect is also evaluated under in vivo conditions by using a rat model infected with bioluminescent S. aureus. The amount of live bacteria in the rat implanted with a nanowire-coated sample is less than that of the control at various time points. Hence, it is believed that the nanowire-coated material is promising for application in orthopaedic implantation after the long-term animal studies have been completed." @default.
- W2284227675 created "2016-06-24" @default.
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- W2284227675 date "2016-05-01" @default.
- W2284227675 modified "2023-10-05" @default.
- W2284227675 title "Development of novel implants with self-antibacterial performance through in-situ growth of 1D ZnO nanowire" @default.
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- W2284227675 doi "https://doi.org/10.1016/j.colsurfb.2016.02.036" @default.
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