FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2284261709> ?p ?o ?g. }

• W2284261709 endingPage "29" @default.
• W2284261709 startingPage "12" @default.
• W2284261709 abstract "The vial capping process is a critical unit operation during drug product manufacturing, as it could possibly generate cosmetic defects or even affect container closure integrity. Yet there is significant variability in capping equipment and processes, and their relation to potential defects or container closure integrity has not been thoroughly studied. In this study we applied several methods-residual seal force tester, a self-developed system of a piezo force sensor measurement, and computed tomography-to characterize different container closure system combinations that had been sealed using different capping process parameter settings. Additionally, container closure integrity of these samples was measured using helium leakage (physical container closure integrity) and compared to characterization data. The different capping equipment settings lead to residual seal force values from 7 to 115 N. High residual seal force values were achieved with high capping pre-compression force and a short distance between the capping plate and plunge. The choice of container closure system influenced the obtained residual seal force values. The residual seal force tester and piezoelectric measurements showed similar trends. All vials passed physical container closure integrity testing, and no stopper rupture was seen with any of the settings applied, suggesting that container closure integrity was warranted for the studied container closure system with the chosen capping setting ranges.The vial capping process is a critical unit operation during drug product manufacturing, as it could possibly generate cosmetic defects or even affect container closure integrity. Yet there is significant variability in capping equipment and processes, and their relation to potential defects or container closure integrity has not been thoroughly studied. In this study we applied several methods-residual seal force tester, a self-developed system of a piezo force sensor measurement, and computed tomography-to characterize different container closure system combinations that had been sealed using different capping process parameter settings. The residual seal force tester can analyze a variety of different container closure systems independent of the capping equipment. An adequate and safe residual seal force range for each container closure system configuration can be established with the residual seal force tester and additional methods like computed tomography scans and leak testing. In the residual seal force range studied, the physical container closure integrity of the container closure system was warranted." @default.
• W2284261709 created "2016-06-24" @default.
• W2284261709 creator A5019399398 @default.
• W2284261709 creator A5020460343 @default.
• W2284261709 creator A5033042277 @default.
• W2284261709 creator A5045938321 @default.
• W2284261709 creator A5049177040 @default.
• W2284261709 creator A5052151636 @default.
• W2284261709 creator A5056287301 @default.
• W2284261709 creator A5071407540 @default.
• W2284261709 creator A5076674254 @default.
• W2284261709 creator A5080472472 @default.
• W2284261709 creator A5087393240 @default.
• W2284261709 date "2016-01-01" @default.
• W2284261709 modified "2023-10-18" @default.
• W2284261709 title "Impact of Vial Capping on Residual Seal Force and Container Closure Integrity" @default.
• W2284261709 cites W157789578 @default.
• W2284261709 cites W1646848978 @default.
• W2284261709 cites W1804806373 @default.
• W2284261709 cites W1921350913 @default.
• W2284261709 cites W2026228241 @default.
• W2284261709 cites W2038864688 @default.
• W2284261709 cites W2111877521 @default.
• W2284261709 cites W2128566918 @default.
• W2284261709 cites W2184327204 @default.
• W2284261709 cites W2204838504 @default.
• W2284261709 cites W2217817557 @default.
• W2284261709 cites W2266131308 @default.
• W2284261709 cites W2396336656 @default.
• W2284261709 cites W2413109134 @default.
• W2284261709 doi "https://doi.org/10.5731/pdajpst.2015.005876" @default.
• W2284261709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26889053" @default.
• W2284261709 hasPublicationYear "2016" @default.
• W2284261709 type Work @default.
• W2284261709 sameAs 2284261709 @default.
• W2284261709 citedByCount "19" @default.
• W2284261709 countsByYear W22842617092016 @default.
• W2284261709 countsByYear W22842617092017 @default.
• W2284261709 countsByYear W22842617092018 @default.
• W2284261709 countsByYear W22842617092019 @default.
• W2284261709 countsByYear W22842617092020 @default.
• W2284261709 countsByYear W22842617092023 @default.
• W2284261709 crossrefType "journal-article" @default.
• W2284261709 hasAuthorship W2284261709A5019399398 @default.
• W2284261709 hasAuthorship W2284261709A5020460343 @default.
• W2284261709 hasAuthorship W2284261709A5033042277 @default.
• W2284261709 hasAuthorship W2284261709A5045938321 @default.
• W2284261709 hasAuthorship W2284261709A5049177040 @default.
• W2284261709 hasAuthorship W2284261709A5052151636 @default.
• W2284261709 hasAuthorship W2284261709A5056287301 @default.
• W2284261709 hasAuthorship W2284261709A5071407540 @default.
• W2284261709 hasAuthorship W2284261709A5076674254 @default.
• W2284261709 hasAuthorship W2284261709A5080472472 @default.
• W2284261709 hasAuthorship W2284261709A5087393240 @default.
• W2284261709 hasConcept C11413529 @default.
• W2284261709 hasConcept C127413603 @default.
• W2284261709 hasConcept C142362112 @default.
• W2284261709 hasConcept C146834321 @default.
• W2284261709 hasConcept C153349607 @default.
• W2284261709 hasConcept C155512373 @default.
• W2284261709 hasConcept C159985019 @default.
• W2284261709 hasConcept C162324750 @default.
• W2284261709 hasConcept C192562407 @default.
• W2284261709 hasConcept C2777755289 @default.
• W2284261709 hasConcept C2781018962 @default.
• W2284261709 hasConcept C34447519 @default.
• W2284261709 hasConcept C41008148 @default.
• W2284261709 hasConcept C77595967 @default.
• W2284261709 hasConceptScore W2284261709C11413529 @default.
• W2284261709 hasConceptScore W2284261709C127413603 @default.
• W2284261709 hasConceptScore W2284261709C142362112 @default.
• W2284261709 hasConceptScore W2284261709C146834321 @default.
• W2284261709 hasConceptScore W2284261709C153349607 @default.
• W2284261709 hasConceptScore W2284261709C155512373 @default.
• W2284261709 hasConceptScore W2284261709C159985019 @default.
• W2284261709 hasConceptScore W2284261709C162324750 @default.
• W2284261709 hasConceptScore W2284261709C192562407 @default.
• W2284261709 hasConceptScore W2284261709C2777755289 @default.
• W2284261709 hasConceptScore W2284261709C2781018962 @default.
• W2284261709 hasConceptScore W2284261709C34447519 @default.
• W2284261709 hasConceptScore W2284261709C41008148 @default.
• W2284261709 hasConceptScore W2284261709C77595967 @default.
• W2284261709 hasIssue "1" @default.
• W2284261709 hasLocation W22842617091 @default.
• W2284261709 hasLocation W22842617092 @default.
• W2284261709 hasOpenAccess W2284261709 @default.
• W2284261709 hasPrimaryLocation W22842617091 @default.
• W2284261709 hasRelatedWork W2014315543 @default.
• W2284261709 hasRelatedWork W2051270029 @default.
• W2284261709 hasRelatedWork W2082293200 @default.
• W2284261709 hasRelatedWork W2137307547 @default.
• W2284261709 hasRelatedWork W2380293314 @default.
• W2284261709 hasRelatedWork W2943188944 @default.
• W2284261709 hasRelatedWork W3008690834 @default.
• W2284261709 hasRelatedWork W3082440218 @default.
• W2284261709 hasRelatedWork W4242480814 @default.
• W2284261709 hasRelatedWork W4285802202 @default.
• W2284261709 hasVolume "70" @default.

• next