Matches in SemOpenAlex for { <https://semopenalex.org/work/W2284273956> ?p ?o ?g. }
- W2284273956 endingPage "e0142798" @default.
- W2284273956 startingPage "e0142798" @default.
- W2284273956 abstract "The centrosome-associated C1orf96/Centriole, Cilia and Spindle-Associated Protein (CSAP) targets polyglutamylated tubulin in mitotic microtubules (MTs). Loss of CSAP causes critical defects in brain development; however, it is unclear how CSAP association with MTs affects mitosis progression. In this study, we explored the molecular mechanisms of the interaction of CSAP with mitotic spindles. Loss of CSAP caused MT instability in mitotic spindles and resulted in mislocalization of Nuclear protein that associates with the Mitotic Apparatus (NuMA), with defective MT dynamics. Thus, CSAP overload in the spindles caused extensive MT stabilization and recruitment of NuMA. Moreover, MT stabilization by CSAP led to high levels of polyglutamylation on MTs. MT depolymerization by cold or nocodazole treatment was inhibited by CSAP binding. Live-cell imaging analysis suggested that CSAP-dependent MT-stabilization led to centrosome-free MT aster formation immediately upon nuclear envelope breakdown without γ-tubulin. We therefore propose that CSAP associates with MTs around centrosomes to stabilize MTs during mitosis, ensuring proper bipolar spindle formation and maintenance." @default.
- W2284273956 created "2016-06-24" @default.
- W2284273956 creator A5028408891 @default.
- W2284273956 creator A5034148097 @default.
- W2284273956 creator A5052720541 @default.
- W2284273956 creator A5080147488 @default.
- W2284273956 date "2015-11-12" @default.
- W2284273956 modified "2023-10-14" @default.
- W2284273956 title "Polyglutamylated Tubulin Binding Protein C1orf96/CSAP Is Involved in Microtubule Stabilization in Mitotic Spindles" @default.
- W2284273956 cites W1829905667 @default.
- W2284273956 cites W1863636479 @default.
- W2284273956 cites W1966723276 @default.
- W2284273956 cites W1977496448 @default.
- W2284273956 cites W1982582935 @default.
- W2284273956 cites W1985499212 @default.
- W2284273956 cites W1986676218 @default.
- W2284273956 cites W1987279648 @default.
- W2284273956 cites W1994058927 @default.
- W2284273956 cites W1994363752 @default.
- W2284273956 cites W2004658596 @default.
- W2284273956 cites W2008852196 @default.
- W2284273956 cites W2011131087 @default.
- W2284273956 cites W2012887006 @default.
- W2284273956 cites W2021467190 @default.
- W2284273956 cites W2028617035 @default.
- W2284273956 cites W2030009398 @default.
- W2284273956 cites W2031805729 @default.
- W2284273956 cites W2036760739 @default.
- W2284273956 cites W2046030002 @default.
- W2284273956 cites W2047308178 @default.
- W2284273956 cites W2054442207 @default.
- W2284273956 cites W2055521821 @default.
- W2284273956 cites W2057733928 @default.
- W2284273956 cites W2058036227 @default.
- W2284273956 cites W2058525645 @default.
- W2284273956 cites W2063724761 @default.
- W2284273956 cites W2076588296 @default.
- W2284273956 cites W2076659391 @default.
- W2284273956 cites W2081937147 @default.
- W2284273956 cites W2082746701 @default.
- W2284273956 cites W2083034193 @default.
- W2284273956 cites W2093396000 @default.
- W2284273956 cites W2112608400 @default.
- W2284273956 cites W2119265777 @default.
- W2284273956 cites W2119471586 @default.
- W2284273956 cites W2121132479 @default.
- W2284273956 cites W2124831548 @default.
- W2284273956 cites W2125148239 @default.
- W2284273956 cites W2132438476 @default.
- W2284273956 cites W2140306229 @default.
- W2284273956 cites W2142993158 @default.
- W2284273956 cites W2143447927 @default.
- W2284273956 cites W2147955440 @default.
- W2284273956 cites W2149067994 @default.
- W2284273956 cites W2152969835 @default.
- W2284273956 cites W2153192086 @default.
- W2284273956 cites W2157103900 @default.
- W2284273956 cites W2157253543 @default.
- W2284273956 cites W2158239169 @default.
- W2284273956 cites W2162546286 @default.
- W2284273956 cites W2164372658 @default.
- W2284273956 cites W2167647748 @default.
- W2284273956 cites W2419272096 @default.
- W2284273956 doi "https://doi.org/10.1371/journal.pone.0142798" @default.
- W2284273956 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4642972" @default.
- W2284273956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26562023" @default.
- W2284273956 hasPublicationYear "2015" @default.
- W2284273956 type Work @default.
- W2284273956 sameAs 2284273956 @default.
- W2284273956 citedByCount "7" @default.
- W2284273956 countsByYear W22842739562016 @default.
- W2284273956 countsByYear W22842739562018 @default.
- W2284273956 countsByYear W22842739562019 @default.
- W2284273956 countsByYear W22842739562020 @default.
- W2284273956 countsByYear W22842739562022 @default.
- W2284273956 countsByYear W22842739562023 @default.
- W2284273956 crossrefType "journal-article" @default.
- W2284273956 hasAuthorship W2284273956A5028408891 @default.
- W2284273956 hasAuthorship W2284273956A5034148097 @default.
- W2284273956 hasAuthorship W2284273956A5052720541 @default.
- W2284273956 hasAuthorship W2284273956A5080147488 @default.
- W2284273956 hasBestOaLocation W22842739561 @default.
- W2284273956 hasConcept C10447061 @default.
- W2284273956 hasConcept C121332964 @default.
- W2284273956 hasConcept C1276947 @default.
- W2284273956 hasConcept C13772937 @default.
- W2284273956 hasConcept C142669718 @default.
- W2284273956 hasConcept C1491633281 @default.
- W2284273956 hasConcept C19269812 @default.
- W2284273956 hasConcept C20418707 @default.
- W2284273956 hasConcept C2779363559 @default.
- W2284273956 hasConcept C29537977 @default.
- W2284273956 hasConcept C3453395 @default.
- W2284273956 hasConcept C47432576 @default.
- W2284273956 hasConcept C48342290 @default.
- W2284273956 hasConcept C54355233 @default.
- W2284273956 hasConcept C70547292 @default.
- W2284273956 hasConcept C84425145 @default.