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• W2284286611 abstract "Abstract Aim Anal screening is recommended in HIV ‐positive patients, especially men who have sex with men ( MSM ), due to an increased incidence of anal cancer. The optimal screening methods are not generally agreed. Method Screening for anal lesions by anorectal examination, including anoscopy, was offered to HIV ‐positive outpatients in a tertiary care university hospital regardless of gender or sexual orientation. Results Among the 1206 screened patients (701 MSM , 247 heterosexual men, 258 women), 311 (26%) had histologically proven lesions related to human papilloma virus ( HPV ) (34% MSM , 14% heterosexual men, 14% women); 123 (10%) had low‐grade dysplasia and 70 (6%) high‐grade dysplasia. Seven anal cancers were also diagnosed. Determinants of any lesion were age < 45 years [ OR = 1.56 (95% CI, 1.16–2.11)], a CD 4 count of < 200/mm 3 [ OR = 2.54 (1.71–3.78)], receptive anal intercourse [ OR =3.03 (2.06–4.47)], sub‐Saharan African origin [ OR = 0.53 (0.33–0.85)], and history of HPV ‐related lesion [ OR = 1.84 (1.35–2.51)]. These determinants were similar for all different grades of dysplasia. In patient subgroup analysis, receptive anal intercourse, the CD 4 cell count and a history of HPV lesions were determinants of HPV ‐positivity in all patients, whereas age was only a determinant in men. Conclusion Anoscopy is an alternative method for anal screening in an HIV ‐positive population. This screening has to be compared with other tools in populations at high risk of anal cancer." @default.
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• W2284286611 date "2016-10-01" @default.
• W2284286611 modified "2023-10-07" @default.
• W2284286611 title "Determinants of macroscopic anal cancer and precancerous lesions in 1206 <scp>HIV</scp>‐infected screened patients" @default.
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• W2284286611 doi "https://doi.org/10.1111/codi.13304" @default.
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