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- W2284356105 abstract "The clinical and morphologic findings observed in some target organs after either continuous or precoital administration of progestogens for purpose of fertility control were compared. Retroprogestagen ethynodiol diacetate norgestrienone and clogestone were taken in a low-dosage continuously by 1472 women for 13875. The same compounds were taken at higher doses only before coitus by 333 women for 1830 months. Subjects were of comparable age parity socioeconomic and educational backgrounds. The precoital regimen was better tolerated with less bleeding and cycle disturbance. Efficacy seems related to the agent and dosage administered. Norgestrienone and Clogestone showed higher efficacy in both regimens than did Retroprogestagen and Ethynodiol diacetate. Modifications in cervical mucus sperm tolerance endometrium and urinary pregnanediol were frequent but not constant. In 60% of the subjects accepted for elective tubal sterilization signs of ovulation were found. Of 71 women who discontinued the low-dosage regimen 77% became pregnant in the same or the first cycle thereafter. Of 51 women discontinuing the precoital regimen fertilization occurred in 70% in the same or the following cycle. Coital use of progestogens seems possible and effective if the proper compound and dose are given." @default.
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- W2284356105 date "1974-01-01" @default.
- W2284356105 modified "2023-10-16" @default.
- W2284356105 title "Low-dosage oral progestogens to control fertility. I. clinical investigation." @default.
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