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- W2284409061 endingPage "292" @default.
- W2284409061 startingPage "257" @default.
- W2284409061 abstract "Despite the existence of huge number of NSAIDs, the quest for safer drugs is still in the focus of several drug discovery programs. Pyrrolizine heterocyclic system is among the privileged scaffolds utilized in this regard. At least one of these pyrrolizines, ketorolac, has reached the market. The current review represents a collective effort to highlight the reported pyrrolizines with anti-inflammatory and analgesic potential and categorize them into eight different classes. Furthermore, the various synthetic approaches, structure-activity relationship as well as metabolic pathways have been discussed. Taken together, this review sets a base for researchers to design and synthesize novel pyrrolizine-based libraries for further development into safer and efficient anti-inflammatory and analgesic agents." @default.
- W2284409061 created "2016-06-24" @default.
- W2284409061 creator A5068230459 @default.
- W2284409061 creator A5074564694 @default.
- W2284409061 date "2016-05-01" @default.
- W2284409061 modified "2023-10-18" @default.
- W2284409061 title "An integrated overview on pyrrolizines as potential anti-inflammatory, analgesic and antipyretic agents" @default.
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- W2284409061 doi "https://doi.org/10.1016/j.ejmech.2016.01.055" @default.
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