FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2284414405> ?p ?o ?g. }

• W2284414405 endingPage "1376" @default.
• W2284414405 startingPage "1369" @default.
• W2284414405 abstract "ABSTRACT Understanding the origin of HIV variants during viral rebound may provide insight into the composition of the HIV reservoir and has implications for the design of curative interventions. HIV single-genome sequences were obtained from 10 AIDS Clinical Trials Group participants who underwent analytic antiretroviral therapy (ART) interruption (ATI). Rebounding variants were compared with those in pre-ART plasma in all 10 participants and with on-ART peripheral blood mononuclear cell (PBMC)-associated DNA and RNA (CA-RNA) in 7/10 participants. The highest viral diversities were found in the DNA and CA-RNA populations. In 3 of 7 participants, we detected multiple, identical DNA and CA-RNA sequences during suppression on ART that exactly matched plasma HIV sequences. Hypermutated DNA and CA-RNA were detected in four participants, contributing to diversities in these compartments that were higher than in the pre-ART and post-ATI plasma. Shifts in the viral rebound populations could be detected in some participants over the 2- to 3-month observation period. These findings suggest that a source of initial rebound viremia could be populations of infected cells that clonally expanded prior to and/or during ART, some of which were already expressing HIV RNA before treatment was interrupted. These clonally expanding populations of HIV-infected cells may represent an important target for strategies aimed at achieving reservoir reduction and sustained virologic remission. IMPORTANCE Antiretroviral therapy alone cannot eradicate the HIV reservoir, and viral rebound is generally rapid after treatment interruption. It has been suggested that clonal expansion of HIV-infected cells is an important mechanism of HIV reservoir persistence, but the contribution of these clonally proliferating cells to the rebounding virus is unknown. We report a study of AIDS Clinical Trials Group participants who underwent treatment interruption and compared rebounding plasma virus with that found within cells prior to treatment interruption. We found several incidences in which plasma HIV variants exactly matched that of multiple proviral DNA copies from infected blood cells sampled before treatment interruption. In addition, we found that these cells were not dormant but were generating unspliced RNA transcripts before treatment was interrupted. Identification of the HIV reservoir and determining its mechanisms for persistence may aid in the development of strategies toward a cure for HIV. (This study was presented in part at the Conference on Retroviruses and Opportunistic Infections, Seattle, WA, February 23 to 26 2015.)" @default.
• W2284414405 created "2016-06-24" @default.
• W2284414405 creator A5027031903 @default.
• W2284414405 creator A5029362932 @default.
• W2284414405 creator A5038307269 @default.
• W2284414405 creator A5038377747 @default.
• W2284414405 creator A5045529124 @default.
• W2284414405 creator A5056797877 @default.
• W2284414405 creator A5065227576 @default.
• W2284414405 creator A5072899489 @default.
• W2284414405 creator A5076674630 @default.
• W2284414405 date "2016-02-01" @default.
• W2284414405 modified "2023-10-12" @default.
• W2284414405 title "Origin of Rebound Plasma HIV Includes Cells with Identical Proviruses That Are Transcriptionally Active before Stopping of Antiretroviral Therapy" @default.
• W2284414405 cites W1549854676 @default.
• W2284414405 cites W1966343819 @default.
• W2284414405 cites W1969276189 @default.
• W2284414405 cites W2015796602 @default.
• W2284414405 cites W2030633257 @default.
• W2284414405 cites W2046159404 @default.
• W2284414405 cites W2055796578 @default.
• W2284414405 cites W2057237578 @default.
• W2284414405 cites W2064416623 @default.
• W2284414405 cites W2072164469 @default.
• W2284414405 cites W2097191915 @default.
• W2284414405 cites W2112117946 @default.
• W2284414405 cites W2114538357 @default.
• W2284414405 cites W2115580899 @default.
• W2284414405 cites W2117678059 @default.
• W2284414405 cites W2125075911 @default.
• W2284414405 cites W2125263596 @default.
• W2284414405 cites W2126603527 @default.
• W2284414405 cites W2136268590 @default.
• W2284414405 cites W2151758275 @default.
• W2284414405 cites W2152365654 @default.
• W2284414405 cites W2154283429 @default.
• W2284414405 cites W2155968113 @default.
• W2284414405 cites W2158867438 @default.
• W2284414405 cites W2163515030 @default.
• W2284414405 cites W2164734631 @default.
• W2284414405 cites W2168795464 @default.
• W2284414405 cites W2169033726 @default.
• W2284414405 cites W2170178664 @default.
• W2284414405 cites W2172297142 @default.
• W2284414405 cites W2327184427 @default.
• W2284414405 doi "https://doi.org/10.1128/jvi.02139-15" @default.
• W2284414405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4719635" @default.
• W2284414405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26581989" @default.
• W2284414405 hasPublicationYear "2016" @default.
• W2284414405 type Work @default.
• W2284414405 sameAs 2284414405 @default.
• W2284414405 citedByCount "114" @default.
• W2284414405 countsByYear W22844144052016 @default.
• W2284414405 countsByYear W22844144052017 @default.
• W2284414405 countsByYear W22844144052018 @default.
• W2284414405 countsByYear W22844144052019 @default.
• W2284414405 countsByYear W22844144052020 @default.
• W2284414405 countsByYear W22844144052021 @default.
• W2284414405 countsByYear W22844144052022 @default.
• W2284414405 countsByYear W22844144052023 @default.
• W2284414405 crossrefType "journal-article" @default.
• W2284414405 hasAuthorship W2284414405A5027031903 @default.
• W2284414405 hasAuthorship W2284414405A5029362932 @default.
• W2284414405 hasAuthorship W2284414405A5038307269 @default.
• W2284414405 hasAuthorship W2284414405A5038377747 @default.
• W2284414405 hasAuthorship W2284414405A5045529124 @default.
• W2284414405 hasAuthorship W2284414405A5056797877 @default.
• W2284414405 hasAuthorship W2284414405A5065227576 @default.
• W2284414405 hasAuthorship W2284414405A5072899489 @default.
• W2284414405 hasAuthorship W2284414405A5076674630 @default.
• W2284414405 hasBestOaLocation W22844144051 @default.
• W2284414405 hasConcept C104317684 @default.
• W2284414405 hasConcept C137061746 @default.
• W2284414405 hasConcept C142462285 @default.
• W2284414405 hasConcept C159047783 @default.
• W2284414405 hasConcept C202751555 @default.
• W2284414405 hasConcept C203014093 @default.
• W2284414405 hasConcept C2776185481 @default.
• W2284414405 hasConcept C2779690655 @default.
• W2284414405 hasConcept C2780727368 @default.
• W2284414405 hasConcept C2993143319 @default.
• W2284414405 hasConcept C3013748606 @default.
• W2284414405 hasConcept C54355233 @default.
• W2284414405 hasConcept C552990157 @default.
• W2284414405 hasConcept C67705224 @default.
• W2284414405 hasConcept C86803240 @default.
• W2284414405 hasConceptScore W2284414405C104317684 @default.
• W2284414405 hasConceptScore W2284414405C137061746 @default.
• W2284414405 hasConceptScore W2284414405C142462285 @default.
• W2284414405 hasConceptScore W2284414405C159047783 @default.
• W2284414405 hasConceptScore W2284414405C202751555 @default.
• W2284414405 hasConceptScore W2284414405C203014093 @default.
• W2284414405 hasConceptScore W2284414405C2776185481 @default.
• W2284414405 hasConceptScore W2284414405C2779690655 @default.
• W2284414405 hasConceptScore W2284414405C2780727368 @default.
• W2284414405 hasConceptScore W2284414405C2993143319 @default.
• W2284414405 hasConceptScore W2284414405C3013748606 @default.
• W2284414405 hasConceptScore W2284414405C54355233 @default.

• next