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- W2284582986 abstract "On the tenth anniversary of two key International Conference on Harmonisation (ICH) guidelines relating to cardiac proarrhythmic safety, an initiative aims to consider the implementation of a new paradigm that combines in vitro and in silico technologies to improve risk assessment. The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative (co-sponsored by the Cardiac Safety Research Consortium, Health and Environmental Sciences Institute, Safety Pharmacology Society and FDA) is a bold and welcome step in using computational tools for regulatory decision making. This review compares and contrasts the state-of-the-art tools from empirical to mechanistic models of cardiac electrophysiology, and how they can and should be used in combination with experimental tests for compound decision making." @default.
- W2284582986 created "2016-06-24" @default.
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- W2284582986 date "2016-06-01" @default.
- W2284582986 modified "2023-09-23" @default.
- W2284582986 title "Recent developments in using mechanistic cardiac modelling for drug safety evaluation" @default.
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