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- W2284599200 abstract "The U.S. Food and Drug Administration (FDA) has just approved a new type of oral contraceptive. Affectionately known as the the new pill contains only one hormone -- 35 mg of the progestin norethindrone. This is in contrast with the conventional oral contraceptive which contains two hormones -- estrogen and progestin. The new pill is taken daily throughout the entire month instead of three weeks in four. The standard pill functions largely by inhibiting ovulation. It is not known how the Mini-pill works but we know that it does not prevent ovulation. Three mechanisms have been suggested: that cervical mucus is prevented from acquireing its liquified phase in mid-cycle and becoming penetrable to the sperm cell; that spermatozoa are prevented from going through the complex process of capacitation from which they gain the capacity to fertilize; or that it renders the lining of the uterus chemically hostile to implantation. There are two distinct disadvantages to the new pill. First association with a higher unplanned pregnancy rate a rate of three per hundred woman years of use instead of one with the ordinary pill. Nevertheless three is still a low pregnancy rate. The second disadvantage is a high incidence of irregular cycles and frequent breadthrough bleeding and spotting. If the new pill is exempt from increased risk of blood clot formation and subsequent embolism occasionally attendant upon use of conventional orals it would have a significant advantage. Since this complication is rare it will require a large army of users to prove or disprove these hopes. Then too some women have unpleasant but not dangerous side effects from standard oral contraceptives and the Mini-pill may be better tolerated by them. Finally physicians have a prejudice perhaps unjustified against preventing ovulation in adolescents early in their menstrual lives; the Mini-pill may be found preferable in this group. It remains to be seen how widely the daily Mini-pill will be accepted in the United States.(Full text)" @default.
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- W2284599200 date "1973-01-01" @default.
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- W2284599200 title "The new pill." @default.
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