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• W2284611504 abstract "Moss, T. J., M. G. Davey, G. J. McCrabb, and R. Harding.Development of ventilatory responsiveness to progressive hypoxia and hypercapnia in low-birth-weight lambs. J. Appl. Physiol. 81(4): 1555–1561, 1996.—Our aim was to determine the effects of low birth weight on ventilatory responses to progressive hypoxia and hypercapnia during early postnatal life. Seven low-birth-weight (2.7 ± 0.3 kg) and five normal-birth-weight (4.8 ± 0.2 kg) lambs, all born at term, underwent weekly rebreathing tests during wakefulness while arterial[Formula: see text],[Formula: see text], and pH were measured. Hypoxic ventilatory responsiveness (HOVR; percent increase in ventilation when arterial [Formula: see text] fell to 60% of resting values) increased in normal lambs from 86.6 ± 7.1% at week 1 to 227.4 ± 24.9% at week 6. In low-birth-weight lambs, HOVR was not significantly different at week 1 (60.1 ± 18.7%) from that of normal lambs but did not increase with postnatal age (56.6 ± 19.3% at week 6). HOVR of all lambs at 6 wk was significantly correlated with birth weight ( r 2 = 0.8). Hypercapnic ventilatory responsiveness (gradient of ventilation vs. arterial [Formula: see text]) did not change with age and was not significantly different between groups [84.7 ± 7.5 (low-birth-weight lambs) vs. 89.4 ± 6.6 ml ⋅ min −1 ⋅ kg −1 ⋅ mmHg −1 (normal lambs)]. We conclude that intrauterine conditions that impair fetal growth lead to the failure of HOVR to increase with age." @default.
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• W2284611504 date "1996-10-01" @default.
• W2284611504 modified "2023-10-18" @default.
• W2284611504 title "Development of ventilatory responsiveness to progressive hypoxia and hypercapnia in low-birth-weight lambs" @default.
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• W2284611504 doi "https://doi.org/10.1152/jappl.1996.81.4.1555" @default.
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