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• W2284696510 abstract "Resistin was discovered in the year 2000. In the mouse, it was reported to be produced by adipocytes and to be linked with insulin resistance and obesity. Human resistin has been shown to be produced by leucocytes but the literature contains contradictory results on its association with obesity and type 2 diabetes. Aim of this study was to clarify the role of resistin in the human context especially in type 2 diabetes and atherosclerosis. The first study examined the possible association of human resistin gene variants with type 2 diabetes. The studied three variants were not associated with type 2 diabetes though they were demonstrated in the second study to be associated with the plasma resistin concentration. However, two gene variants were associated with the prevalence of cerebrovascular disease in subjects with type 2 diabetes. In the third work, the association of the plasma resistin level with the risk factors of atherosclerosis and early atherosclerosis measured with carotid artery intima-media thickness (IMT) were studied. Plasma resistin level was not associated with IMT independently from the known risk factors of atherosclerosis. However, resistin was associated with inflammatory markers highly sensitive CRP and the number of leucocytes whereas insulin resistance did not associate with resistin. In the fourth study, resistin expression in different leucocytes and its modulation, as well as the effect of resistin on monocyte adhesion to endothelium were evaluated. The novel discovery was that resistin is expressed in all the main leucocyte lineages, with monocytes and neutrophils exhibiting the highest relative mRNA and protein levels of resistin. Resistin expression was upregulated by pro-inflammatory factors in the cells of both innate and adaptive immunity. The present results demonstrating that resistin increases adhesion and expression of some adhesion molecules support the hypothesis that resistin may be involved in the development of atherosclerosis. The above results indicate that resistin is widely produced by leucocytes and therefore may participate in inflammatory processes. Since it may be considered as an inflammatory cytokine, resistin may also influence the development of atherosclerosis. In the future, resistin could possibly be used as a marker of inflammation." @default.
• W2284696510 created "2016-06-24" @default.
• W2284696510 creator A5084541543 @default.
• W2284696510 date "2008-01-01" @default.
• W2284696510 modified "2023-09-27" @default.
• W2284696510 title "Genetic, epidemiological and cell culture studies on human resistin" @default.
• W2284696510 cites W126654348 @default.
• W2284696510 cites W1539459415 @default.
• W2284696510 cites W1551600243 @default.
• W2284696510 cites W1580333814 @default.
• W2284696510 cites W1587656579 @default.
• W2284696510 cites W1607206333 @default.
• W2284696510 cites W1650965741 @default.
• W2284696510 cites W1675830194 @default.
• W2284696510 cites W1708748675 @default.
• W2284696510 cites W1907219612 @default.
• W2284696510 cites W1919647167 @default.
• W2284696510 cites W1931320689 @default.
• W2284696510 cites W1964044812 @default.
• W2284696510 cites W1964863934 @default.
• W2284696510 cites W1969040344 @default.
• W2284696510 cites W1969973773 @default.
• W2284696510 cites W1970701005 @default.
• W2284696510 cites W1972967644 @default.
• W2284696510 cites W1974159561 @default.
• W2284696510 cites W1974379522 @default.
• W2284696510 cites W1975758736 @default.
• W2284696510 cites W1976295619 @default.
• W2284696510 cites W1976329330 @default.
• W2284696510 cites W1976895143 @default.
• W2284696510 cites W1980728386 @default.
• W2284696510 cites W1980950685 @default.
• W2284696510 cites W1984057531 @default.
• W2284696510 cites W1985937275 @default.
• W2284696510 cites W1987058768 @default.
• W2284696510 cites W1987328358 @default.
• W2284696510 cites W1987963517 @default.
• W2284696510 cites W1988099321 @default.
• W2284696510 cites W1988800094 @default.
• W2284696510 cites W1989200821 @default.
• W2284696510 cites W1989579799 @default.
• W2284696510 cites W1989998444 @default.
• W2284696510 cites W1990465836 @default.
• W2284696510 cites W1990757970 @default.
• W2284696510 cites W1991804203 @default.
• W2284696510 cites W1992046125 @default.
• W2284696510 cites W1992293980 @default.
• W2284696510 cites W1993433679 @default.
• W2284696510 cites W1995167724 @default.
• W2284696510 cites W1997064587 @default.
• W2284696510 cites W1998634450 @default.
• W2284696510 cites W1999474387 @default.
• W2284696510 cites W1999744765 @default.
• W2284696510 cites W2000286377 @default.
• W2284696510 cites W2001137653 @default.
• W2284696510 cites W2001562320 @default.
• W2284696510 cites W2002504985 @default.
• W2284696510 cites W2002513977 @default.
• W2284696510 cites W2003652884 @default.
• W2284696510 cites W2008215609 @default.
• W2284696510 cites W2008869160 @default.
• W2284696510 cites W2009354994 @default.
• W2284696510 cites W2009702197 @default.
• W2284696510 cites W2019750072 @default.
• W2284696510 cites W2022464927 @default.
• W2284696510 cites W2024691095 @default.
• W2284696510 cites W2025904060 @default.
• W2284696510 cites W2027091986 @default.
• W2284696510 cites W2028288720 @default.
• W2284696510 cites W2029631026 @default.
• W2284696510 cites W2030778616 @default.
• W2284696510 cites W2030841143 @default.
• W2284696510 cites W2033659078 @default.
• W2284696510 cites W2034239523 @default.
• W2284696510 cites W2037021965 @default.
• W2284696510 cites W2037251283 @default.
• W2284696510 cites W2037548392 @default.
• W2284696510 cites W2038459771 @default.
• W2284696510 cites W2038551245 @default.
• W2284696510 cites W2038687706 @default.
• W2284696510 cites W2038961236 @default.
• W2284696510 cites W2039620410 @default.
• W2284696510 cites W2041622580 @default.
• W2284696510 cites W2043439822 @default.
• W2284696510 cites W2043927538 @default.
• W2284696510 cites W2044082769 @default.
• W2284696510 cites W2044215373 @default.
• W2284696510 cites W2045541101 @default.
• W2284696510 cites W2046387295 @default.
• W2284696510 cites W2047214970 @default.
• W2284696510 cites W2048613141 @default.
• W2284696510 cites W2049804506 @default.
• W2284696510 cites W2053973709 @default.
• W2284696510 cites W2054316063 @default.
• W2284696510 cites W2055520368 @default.
• W2284696510 cites W2056456033 @default.
• W2284696510 cites W2056788930 @default.
• W2284696510 cites W2056986474 @default.
• W2284696510 cites W2057348780 @default.
• W2284696510 cites W2057651652 @default.

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