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- W2284735220 abstract "Middle-aged and older (MA/O) adults who perform habitual aerobic exercise demonstrate enhanced vascular endothelial function compared with their sedentary peers, but the molecular mechanisms involved are unknown. Brachial artery flow-mediated dilation, a measure of endothelium-dependent dilation, was 34% higher (6.8 ± 0.9 vs. 5.1 ± 0.4 %δ, P<0.05) in regularly exercising (EX, n=12, 62 ± 2 yrs, 8M/4F) vs. sedentary (SED; n=25, age 62 ± 1 yrs, 12M/13F) healthy MA/O adults, whereas endothelium-independent dilation to sublingual nitroglycerin was not different (29.3 ± 1.8 vs. 26.7 ± 1.4 %δ, P=0.29). In endothelial cells obtained from the brachial artery, expression of nitrotyrosine (NT), a cellular marker of oxidative stress (0.48 ± 0.07 vs. 0.74 ± 0.10 immunofluorescent intensity/HUVEC intensity), NADPH oxidase p47phox, a subunit of the oxidant enzyme NADPH oxidase (0.41 ± 0.04 vs. 0.76 ± 0.09), and nuclear factor κB (NFκB), a redox-sensitive proinflammatory transcription factor (0.39 ± 0.04 vs. 0.64 ± 0.06), were 35-50% lower in EX, whereas manganese superoxide dismutase (MnSOD), a mitochondrial antioxidant enzyme, was 74% higher (0.48 ± 0.07 vs. 0.28 ± 0.04) (all P<0.05 vs. SED). NT was positively related to NADPH oxidase p47phox (r=0.64, P<0.01) and NFκB (r=0.29, P=0.05), but not to MnSOD. Compared with their sedentary peers, habitually exercising MA/O adults have reduced vascular endothelial cell oxidative stress related to decreased NADPH oxidase and NFκB. Supported by NIH AG000279, AG013038, AG022241, AG006537, and RR00051." @default.
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- W2284735220 date "2009-04-01" @default.
- W2284735220 modified "2023-10-12" @default.
- W2284735220 title "Habitual aerobic exercise is associated with reduced vascular endothelial cell oxidative stress, NADPH oxidase and NFκB in middle‐aged and older humans" @default.
- W2284735220 doi "https://doi.org/10.1096/fasebj.23.1_supplement.955.18" @default.
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