Matches in SemOpenAlex for { <https://semopenalex.org/work/W2284769570> ?p ?o ?g. }
- W2284769570 endingPage "1109" @default.
- W2284769570 startingPage "1099" @default.
- W2284769570 abstract "Chronic traumatic encephalopathy (CTE) is a tauopathy associated with prior exposure to repetitive head impacts, such as those incurred through American football and other collision sports. Diagnosis is made through neuropathological examination. Many of the clinical features of CTE are common in the general population, with and without a history of head impact exposure, making clinical diagnosis difficult. As is now common in the diagnosis of other neurodegenerative disorders, such as Alzheimer's disease, there is a need for methods to diagnose CTE during life through objective biomarkers.The aim of this study was to examine tau-positive exosomes in plasma as a potential CTE biomarker.Subjects were 78 former National Football League (NFL) players and 16 controls. Extracellular vesicles were isolated from plasma. Fluorescent nanoparticle tracking analysis was used to determine the number of vesicles staining positive for tau.The NFL group had higher exosomal tau than the control group (p < 0.0001). Exosomal tau discriminated between the groups, with 82% sensitivity, 100% specificity, 100% positive predictive value, and 53% negative predictive value. Within the NFL group, higher exosomal tau was associated with worse performance on tests of memory (p = 0.0126) and psychomotor speed (p = 0.0093).These preliminary findings suggest that exosomal tau in plasma may be an accurate, noninvasive CTE biomarker." @default.
- W2284769570 created "2016-06-24" @default.
- W2284769570 creator A5008524903 @default.
- W2284769570 creator A5012711279 @default.
- W2284769570 creator A5015397419 @default.
- W2284769570 creator A5018010485 @default.
- W2284769570 creator A5020082463 @default.
- W2284769570 creator A5023123457 @default.
- W2284769570 creator A5027018307 @default.
- W2284769570 creator A5036658984 @default.
- W2284769570 creator A5056184501 @default.
- W2284769570 creator A5069601786 @default.
- W2284769570 creator A5087529088 @default.
- W2284769570 creator A5088677579 @default.
- W2284769570 creator A5090524010 @default.
- W2284769570 date "2016-04-12" @default.
- W2284769570 modified "2023-10-11" @default.
- W2284769570 title "Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy" @default.
- W2284769570 cites W1483140595 @default.
- W2284769570 cites W1504740480 @default.
- W2284769570 cites W1509269112 @default.
- W2284769570 cites W1562805394 @default.
- W2284769570 cites W1590917599 @default.
- W2284769570 cites W1617802654 @default.
- W2284769570 cites W1757342530 @default.
- W2284769570 cites W1771394546 @default.
- W2284769570 cites W1797408175 @default.
- W2284769570 cites W1816716886 @default.
- W2284769570 cites W1843712425 @default.
- W2284769570 cites W1877078532 @default.
- W2284769570 cites W1887821162 @default.
- W2284769570 cites W1888623186 @default.
- W2284769570 cites W1931623992 @default.
- W2284769570 cites W1944945174 @default.
- W2284769570 cites W1965201584 @default.
- W2284769570 cites W1974384388 @default.
- W2284769570 cites W1981058545 @default.
- W2284769570 cites W1985345440 @default.
- W2284769570 cites W1995903088 @default.
- W2284769570 cites W1999684482 @default.
- W2284769570 cites W2001422009 @default.
- W2284769570 cites W2005671109 @default.
- W2284769570 cites W2007824057 @default.
- W2284769570 cites W2018593076 @default.
- W2284769570 cites W2020864657 @default.
- W2284769570 cites W2021267750 @default.
- W2284769570 cites W2025935987 @default.
- W2284769570 cites W2032936850 @default.
- W2284769570 cites W2038034523 @default.
- W2284769570 cites W2041011865 @default.
- W2284769570 cites W2043666690 @default.
- W2284769570 cites W2048940820 @default.
- W2284769570 cites W2052135835 @default.
- W2284769570 cites W2059516728 @default.
- W2284769570 cites W2067495470 @default.
- W2284769570 cites W2070632079 @default.
- W2284769570 cites W2071105928 @default.
- W2284769570 cites W2071188263 @default.
- W2284769570 cites W2079830794 @default.
- W2284769570 cites W2081325915 @default.
- W2284769570 cites W2083054399 @default.
- W2284769570 cites W2086518820 @default.
- W2284769570 cites W2087014941 @default.
- W2284769570 cites W2088433111 @default.
- W2284769570 cites W2090523774 @default.
- W2284769570 cites W2097774418 @default.
- W2284769570 cites W2099340413 @default.
- W2284769570 cites W2107447135 @default.
- W2284769570 cites W2110282732 @default.
- W2284769570 cites W2114613490 @default.
- W2284769570 cites W2114679345 @default.
- W2284769570 cites W2115017507 @default.
- W2284769570 cites W2115866516 @default.
- W2284769570 cites W2116016048 @default.
- W2284769570 cites W2116709840 @default.
- W2284769570 cites W2122110838 @default.
- W2284769570 cites W2124200927 @default.
- W2284769570 cites W2125001590 @default.
- W2284769570 cites W2126028421 @default.
- W2284769570 cites W2127201752 @default.
- W2284769570 cites W2131001963 @default.
- W2284769570 cites W2134097886 @default.
- W2284769570 cites W2135176618 @default.
- W2284769570 cites W2141679195 @default.
- W2284769570 cites W2149936124 @default.
- W2284769570 cites W2152462550 @default.
- W2284769570 cites W2155280727 @default.
- W2284769570 cites W2156511539 @default.
- W2284769570 cites W2164239948 @default.
- W2284769570 cites W2166166580 @default.
- W2284769570 cites W2190404250 @default.
- W2284769570 cites W2217184110 @default.
- W2284769570 cites W2217974487 @default.
- W2284769570 cites W2319148338 @default.
- W2284769570 cites W2737966001 @default.
- W2284769570 cites W4256049924 @default.
- W2284769570 cites W4362221370 @default.
- W2284769570 cites W47608607 @default.