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• W2284857870 endingPage "G963" @default.
• W2284857870 startingPage "G955" @default.
• W2284857870 abstract "Intracellular microelectrodes were used to record neurogenic inhibitory junction potentials in the intestinal circular muscle coat. Electrical field stimulation was used to stimulate intramural neurons and evoke contraction of the smooth musculature. Exposure to β-nicotinamide adenine dinucleotide (β-NAD) did not alter smooth muscle membrane potential in guinea pig colon or human jejunum. ATP, ADP, β-NAD, and adenosine, as well as the purinergic P2Y 1 receptor antagonists MRS 2179 and MRS 2500 and the adenosine A 1 receptor agonist 2-chloro- N 6 -cyclopentyladenosine, each suppressed inhibitory junction potentials in guinea pig and human preparations. β-NAD suppressed contractile force of twitch-like contractions evoked by electrical field stimulation in guinea pig and human preparations. P2Y 1 receptor antagonists did not reverse this action. Stimulation of adenosine A 1 receptors with 2-chloro- N 6 -cyclopentyladenosine suppressed the force of twitch contractions evoked by electrical field stimulation in like manner to the action of β-NAD. Blockade of adenosine A 1 receptors with 8-cyclopentyl-1,3-dipropylxanthine suppressed the inhibitory action of β-NAD on the force of electrically evoked contractions. The results do not support an inhibitory neurotransmitter role for β-NAD at intestinal neuromuscular junctions. The data suggest that β-NAD is a ligand for the adenosine A 1 receptor subtype expressed by neurons in the enteric nervous system. The influence of β-NAD on intestinal motility emerges from adenosine A 1 receptor-mediated suppression of neurotransmitter release at inhibitory neuromuscular junctions." @default.
• W2284857870 created "2016-06-24" @default.
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• W2284857870 date "2015-06-01" @default.
• W2284857870 modified "2023-09-27" @default.
• W2284857870 title "β-Nicotinamide adenine dinucleotide acts at prejunctional adenosine A₁ receptors to suppress inhibitory musculomotor neurotransmission in guinea pig colon and human jejunum" @default.
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• W2284857870 doi "https://doi.org/10.1152/ajpgi.00430.2014" @default.
• W2284857870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4451321" @default.
• W2284857870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25813057" @default.
• W2284857870 hasPublicationYear "2015" @default.
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