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- W2284915330 abstract "This study reports on potential protective effect of pioglitazone against functional, biochemical, and histological vascular derangements caused by cyclosporine (CSA) in rats. CSA (20 mg/kg/day, s.c., for 14 days) impaired aortic vasorelaxations induced by carbachol. The EC50 and Emax of carbachol were'/significantly increased and decreased, respectively, by CSA. These effects of CSA were abolished upon concurrent exposure to pioglitazone (2.5 mg/kg/day). In contrast, aortic responses to sodium nitroprusside, an endothelium-independent vasorelaxant, were not altered by CSA. The possibility that alterations in the antioxidant and/or lipid profile contributed to the CSA-pioglitazone interaction was investigated. CSA caused deterioration of the aortic antioxidant capacity as suggested by the decreases in superoxide dismutase activity and increases in malondialdyde and nitrite/nitrate levels. Further, CSA increased serum LDL and LDL/HDL ratio, effects that were also abrogated by simultaneous administration of pioglitazone. Histologically, CSA caused focal disruption in the endothelial lining of the aorta and this effect disappeared in presence of pioglitazone. These findings highlight a protective effect for pioglitazone against the vasculotoxic action of CSA and perhaps underlying oxidative and dyslipidemic effects." @default.
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- W2284915330 date "2010-04-01" @default.
- W2284915330 modified "2023-09-26" @default.
- W2284915330 title "Improved Antioxidant And Lipid Profiles Underlie The Protective Effect Of Pioglitazone Against Cyclosporine‐Induced Endothelium Dysfunction In Isolated Rat Aortas" @default.
- W2284915330 doi "https://doi.org/10.1096/fasebj.24.1_supplement.961.13" @default.
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