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• W2285073903 startingPage "149" @default.
• W2285073903 abstract "The lipid mediator prostanoids consist of prostaglandins and thromboxanes, and are synthesized from arachidonic acid by the action of cyclooxygenase. There are five major prostanoids, including prostaglandin E2 (PGE2), and they are involved in a variety of biological responses such as inflammation, allergy, parturition, and tumorigenesis. These prostanoids exert their effects via activation of their cognate G protein coupled receptors, e.g., E-type prostanoid (EP) receptors for PGE2. The EP receptors are composed of four subtypes, namely EP1 to EP4. Here, breakthroughs in the last dozen years of research are introduced, with a special focus on some important findings of EP4 receptor-mediated signaling and the signaling associated with cancer development, particularly in colon cancer." @default.
• W2285073903 created "2016-06-24" @default.
• W2285073903 creator A5089867564 @default.
• W2285073903 date "2016-01-01" @default.
• W2285073903 modified "2023-10-14" @default.
• W2285073903 title "The Roles of EP4 Prostanoid Receptors in Cancer Malignancy Signaling" @default.
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• W2285073903 doi "https://doi.org/10.1248/bpb.b15-00840" @default.
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