FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2285147526> ?p ?o ?g. }

• W2285147526 endingPage "768" @default.
• W2285147526 startingPage "760" @default.
• W2285147526 abstract "OBJECTIVE The purpose of this study was to evaluate the 7-year cost-effectiveness of cervical total disc replacement (CTDR) versus anterior cervical discectomy and fusion (ACDF) for the treatment of patients with single-level symptomatic degenerative disc disease. A change in the spending trajectory for spine care is to be achieved, in part, through the selection of interventions that have been proven effective yet cost less than other options. This analysis complements and builds upon findings from other cost-effectiveness evaluations of CTDR through the use of long-term, patient-level data from a randomized study. METHODS This was a 7-year health economic evaluation comparing CTDR versus ACDF from the US commercial payer perspective. Prospectively collected health care resource utilization and treatment effects (quality-adjusted life years [QALYs]) were obtained from individual patient-level adverse event reports and SF-36 data, respectively, from the randomized, multicenter ProDisc-C total disc replacement investigational device exemption (IDE) study and post-approval study. Statistical distributions for unit costs were derived from a commercial claims database and applied using Monte Carlo simulation. Patient-level costs and effects were modeled via multivariate probabilistic analysis. Confidence intervals for 7-year costs, effects, and net monetary benefit (NMB) were obtained using the nonparametric percentile method from results of 10,000 bootstrap simulations. The robustness of results was assessed through scenario analysis and within a parametric regression model controlling for baseline variables. RESULTS Seven-year follow-up data were available for more than 70% of the 209 randomized patients. In the base-case analysis, CTDR resulted in mean per-patient cost savings of $12,789 (95% CI $5362–$20,856) and per-patient QALY gains of 0.16 (95% CI −0.073 to 0.39) compared with ACDF over 7 years. CTDR was more effective and less costly in 90.8% of probabilistic simulations. CTDR was cost-effective in 99.8% of sensitivity analysis simulations and generated a mean incremental NMB of $20,679 (95% CI $6053–$35,377) per patient at a willingness-to-pay threshold of $50,000/QALY. CONCLUSIONS Based on this modeling evaluation, CTDR was found to be more effective and less costly over a 7-year time horizon for patients with single-level symptomatic degenerative disc disease. These results are robust across a range of scenarios and perspectives and are intended to support value-based decision making." @default.
• W2285147526 created "2016-06-24" @default.
• W2285147526 creator A5007811838 @default.
• W2285147526 creator A5025220126 @default.
• W2285147526 creator A5030126344 @default.
• W2285147526 creator A5076342250 @default.
• W2285147526 creator A5077034829 @default.
• W2285147526 date "2016-05-01" @default.
• W2285147526 modified "2023-10-16" @default.
• W2285147526 title "Seven-year cost-effectiveness of ProDisc-C total disc replacement: results from investigational device exemption and post-approval studies" @default.
• W2285147526 cites W1488157144 @default.
• W2285147526 cites W1490528568 @default.
• W2285147526 cites W1552924121 @default.
• W2285147526 cites W1663765989 @default.
• W2285147526 cites W1895111093 @default.
• W2285147526 cites W1937705451 @default.
• W2285147526 cites W1965742808 @default.
• W2285147526 cites W1969104459 @default.
• W2285147526 cites W1975674888 @default.
• W2285147526 cites W1979891106 @default.
• W2285147526 cites W1982564323 @default.
• W2285147526 cites W1997336301 @default.
• W2285147526 cites W2015748473 @default.
• W2285147526 cites W2031100450 @default.
• W2285147526 cites W2031286844 @default.
• W2285147526 cites W2031755191 @default.
• W2285147526 cites W2035780773 @default.
• W2285147526 cites W2040342502 @default.
• W2285147526 cites W2042194155 @default.
• W2285147526 cites W2042968830 @default.
• W2285147526 cites W2043024153 @default.
• W2285147526 cites W2043951092 @default.
• W2285147526 cites W2047992411 @default.
• W2285147526 cites W2050893190 @default.
• W2285147526 cites W2051345206 @default.
• W2285147526 cites W2056020190 @default.
• W2285147526 cites W2063018897 @default.
• W2285147526 cites W2065814191 @default.
• W2285147526 cites W2077481395 @default.
• W2285147526 cites W2084745043 @default.
• W2285147526 cites W2092052931 @default.
• W2285147526 cites W2115308689 @default.
• W2285147526 cites W2117419474 @default.
• W2285147526 cites W2124246278 @default.
• W2285147526 cites W2127885350 @default.
• W2285147526 cites W2136152204 @default.
• W2285147526 cites W2152147591 @default.
• W2285147526 cites W2160315143 @default.
• W2285147526 cites W2323553903 @default.
• W2285147526 cites W2332998458 @default.
• W2285147526 cites W3121539865 @default.
• W2285147526 doi "https://doi.org/10.3171/2015.10.spine15505" @default.
• W2285147526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26824587" @default.
• W2285147526 hasPublicationYear "2016" @default.
• W2285147526 type Work @default.
• W2285147526 sameAs 2285147526 @default.
• W2285147526 citedByCount "37" @default.
• W2285147526 countsByYear W22851475262017 @default.
• W2285147526 countsByYear W22851475262018 @default.
• W2285147526 countsByYear W22851475262019 @default.
• W2285147526 countsByYear W22851475262020 @default.
• W2285147526 countsByYear W22851475262021 @default.
• W2285147526 countsByYear W22851475262022 @default.
• W2285147526 countsByYear W22851475262023 @default.
• W2285147526 crossrefType "journal-article" @default.
• W2285147526 hasAuthorship W2285147526A5007811838 @default.
• W2285147526 hasAuthorship W2285147526A5025220126 @default.
• W2285147526 hasAuthorship W2285147526A5030126344 @default.
• W2285147526 hasAuthorship W2285147526A5076342250 @default.
• W2285147526 hasAuthorship W2285147526A5077034829 @default.
• W2285147526 hasBestOaLocation W22851475261 @default.
• W2285147526 hasConcept C126322002 @default.
• W2285147526 hasConcept C141071460 @default.
• W2285147526 hasConcept C159110408 @default.
• W2285147526 hasConcept C168563851 @default.
• W2285147526 hasConcept C1862650 @default.
• W2285147526 hasConcept C197934379 @default.
• W2285147526 hasConcept C2778051963 @default.
• W2285147526 hasConcept C2778620186 @default.
• W2285147526 hasConcept C2779951463 @default.
• W2285147526 hasConcept C2781430139 @default.
• W2285147526 hasConcept C2985379065 @default.
• W2285147526 hasConcept C44575665 @default.
• W2285147526 hasConcept C535046627 @default.
• W2285147526 hasConcept C71924100 @default.
• W2285147526 hasConceptScore W2285147526C126322002 @default.
• W2285147526 hasConceptScore W2285147526C141071460 @default.
• W2285147526 hasConceptScore W2285147526C159110408 @default.
• W2285147526 hasConceptScore W2285147526C168563851 @default.
• W2285147526 hasConceptScore W2285147526C1862650 @default.
• W2285147526 hasConceptScore W2285147526C197934379 @default.
• W2285147526 hasConceptScore W2285147526C2778051963 @default.
• W2285147526 hasConceptScore W2285147526C2778620186 @default.
• W2285147526 hasConceptScore W2285147526C2779951463 @default.
• W2285147526 hasConceptScore W2285147526C2781430139 @default.
• W2285147526 hasConceptScore W2285147526C2985379065 @default.
• W2285147526 hasConceptScore W2285147526C44575665 @default.
• W2285147526 hasConceptScore W2285147526C535046627 @default.

• next