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- W2285162783 abstract "We aimed to idenify heart failure genes by using a rat model of the human disease. We performed invasive cardiac hemodynamic measurements in F2 crosses using spontaneously hypertensive heart failure rats (SHHF) and reference strains. We combined linkage analyses with genome wide expression profiling and identified Ephx2 as heart failure susceptibility gene in SHHF. We demonstrate that cis-variation at Ephx2 co-segregated with heart failure, increased transcript expression, protein expression, and enzyme activity, leading to a more rapid hydrolysis of cardioprotective epoxyeicosatrienoic acids. To confirm our results, we next tested the role of Ephx2 in heart failure by using knockout mice. We show that Ephx2 gene ablation protects from pressure overload-induced heart failure and cardiac arrhythmias. We further demonstrate differential regulation of Ephx2 in human heart failure suggesting a cross-species role for Ephx2 in this complex disease." @default.
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- W2285162783 date "2008-03-01" @default.
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- W2285162783 title "Soluble epoxide hydrolase (Ephx2) is a susceptibility gene for heart failure in a rat model of human disease 3044" @default.
- W2285162783 doi "https://doi.org/10.1096/fasebj.22.1_supplement.479.10" @default.
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