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• W2285228239 endingPage "2826" @default.
• W2285228239 startingPage "2816" @default.
• W2285228239 abstract "ABSTRACT Inflammation is a major cause of respiratory impairment during Pneumocystis pneumonia. Studies support a significant role for cell wall β-glucans in stimulating inflammatory responses. Fungal β-glucans are comprised of d -glucose homopolymers containing β-1,3-linked glucose backbones with β-1,6-linked glucose side chains. Prior studies in Pneumocystis carinii have characterized β-1,3 glucan components of the organism. However, recent investigations in other organisms support important roles for β-1,6 glucans, predominantly in mediating host cellular activation. Accordingly, we sought to characterize β-1,6 glucans in the cell wall of Pneumocystis and to establish their activity in lung cell inflammation. Immune staining revealed specific β-1,6 localization in P. carinii cyst walls. Homology-based cloning facilitated characterization of a functional P. carinii kre6 ( Pckre6 ) β-1,6 glucan synthase in Pneumocystis that, when expressed in kre6 -deficient Saccharomyces cerevisiae , restored cell wall stability. Recently synthesized β-1,6 glucan synthase inhibitors decreased the ability of isolated P. carinii preparations to generate β-1,6 carbohydrate. In addition, isolated β-1,6 glucan fractions from Pneumocystis elicited vigorous tumor necrosis factor alpha (TNF-α) responses from macrophages. These inflammatory responses were significantly dampened by inhibition of host cell plasma membrane microdomain function. Together, these studies indicate that β-1,6 glucans are present in the P. carinii cell wall and contribute to lung cell inflammatory activation during infection." @default.
• W2285228239 created "2016-06-24" @default.
• W2285228239 creator A5021530553 @default.
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• W2285228239 creator A5053804590 @default.
• W2285228239 creator A5059447812 @default.
• W2285228239 creator A5091376137 @default.
• W2285228239 date "2015-07-01" @default.
• W2285228239 modified "2023-10-03" @default.
• W2285228239 title "Evidence for Proinflammatory β-1,6 Glucans in the Pneumocystis carinii Cell Wall" @default.
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• W2285228239 doi "https://doi.org/10.1128/iai.00196-15" @default.
• W2285228239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4468544" @default.
• W2285228239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25916991" @default.
• W2285228239 hasPublicationYear "2015" @default.
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