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• W2285237309 abstract "<h3>Objective:</h3> To investigate whether a serotonin-to-dopamine terminal ratio is related to the appearance of dyskinesias in patients with Parkinson disease (PD). <h3>Methods:</h3> Twenty-eight patients with idiopathic PD (17 with levodopa-induced dyskinesias [LIDs], 11 without dyskinesias) and 12 age-matched healthy controls were studied with PET and 5[¹¹C]-3-amino-4-(2-dimethylaminomethylphenyl-sulfanyl)-benzonitrile (¹¹C-DASB) and with SPECT and [¹²³I]N-w-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (¹²³I-ioflupane), which are in vivo specific markers of the serotonin and dopamine transporters9 availability, respectively. We have employed a simplified reference tissue model for the quantification of ¹¹C-DASB, whereas a semiquantification approach was used for ¹²³I-ioflupane data. We calculated ¹¹C-DASB binding to ¹²³I-ioflupane uptake ratios for the caudate and the putamen. <h3>Results:</h3> Patients with PD showed striatal decreases in ¹¹C-DASB binding potential (<i>p</i> < 0.01) and in ¹²³I-ioflupane mean uptake (<i>p</i> < 0.001) compared to controls. The mean ¹¹C-DASB binding to ¹²³I-ioflupane uptake ratio in the putamen was 0.779 (increased by 75.8% of the controls9 mean) for the nondyskinetic group and 0.901 (increased by 103.4% of the controls9 mean) for the patients with dyskinesias. There was a statistically significant difference (<i>p</i> < 0.001) in ¹¹C-DASB binding to ¹²³I-ioflupane uptake ratio in the putamen between the group of patients with and without dyskinesias. Higher ¹¹C-DASB to ¹²³I-ioflupane binding ratios correlated with longer disease duration for the 28 patients with PD (<i>r</i> = 0.52; <i>p</i> < 0.01). <h3>Conclusions:</h3> Serotonin-to-dopamine transporter binding ratio increases as PD progresses and patients experience LIDs. Our findings suggest that, when the dopaminergic innervation in the striatum is critically low, the serotonergic system plays an important role in development of LIDs." @default.
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• W2285237309 date "2016-02-26" @default.
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• W2285237309 title "Serotonin-to-dopamine transporter ratios in Parkinson disease" @default.
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