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- W2285248776 abstract "With the discovery of the anticardiolipin antibodies in 1983 and subsequent research on the antiphospholipid antibodies over the ensuing 20 years, many of the clinical events and paradoxes in this field before this time have been explained. Although a positive lupus anticoagulant test (a functional clotting test performed by most laboratories) was at first thought to be due to the presence of interfering antibodies against phospholipids, an integral part of the clotting process, it has since been shown that these antibodies are directed against proteins. The binding of phospholipid to certain domains on one protein in particular (beta 2 glycoprotein 1 (β2GP1), one of the body’s natural anticoagulants) alters the conformation of peptides at certain positions on the molecule, forming what is known as a cryptic epitope or neoantigen against which the antiphospholipid antibodies are directed (Fig. 1)." @default.
- W2285248776 created "2016-06-24" @default.
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- W2285248776 date "2008-03-19" @default.
- W2285248776 modified "2023-09-25" @default.
- W2285248776 title "Antiphospholipid antibodies and syndromes: relevance for the GP" @default.
- W2285248776 hasPublicationYear "2008" @default.
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