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- W2285275077 abstract "Lung organogenesis involves the emergence of the lung anlage from the anterior foregut, laryngeal and tracheoesophageal morphogenesis and septation, tracheal bifurcation, patterning of the major bronchi, lobation of the lungs, branching morphogenesis of approximately 23 generations of airways, and formation of alveoli.1 In the third week of gestation, the lung begins to develop as a ventral outpouching on the floor of the primitive foregut.2 The lung’s development may be divided into five phases: the embryonic, pseudoglandular, acinar or canalicular, saccular, and alveolar phases.2–4 A variety of factors influence normal lung development, including normal fetal breathing movements, adequate intrathoracic space, appropriate volumes of extra- and intrapulmonary fluid, pulmonary blood flow, as well as maternal factors such as nutrition and smoking.3 The foregut endoderm differentiates into epithelial cell types that line the developing lung and trachea, whereas lungmesenchyme originates from the lateral plate mesoderm and develops into several lung components, including connective tissue, smooth muscle surrounding airways and medium- and small-sized blood vessels, endothelial cell precursors, lymphatics, tracheal cartilage, and pleura.5" @default.
- W2285275077 created "2016-06-24" @default.
- W2285275077 creator A5001433808 @default.
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- W2285275077 date "2008-01-01" @default.
- W2285275077 modified "2023-09-23" @default.
- W2285275077 title "Pulmonary Organogenesis and Developmental Abnormalities" @default.
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- W2285275077 doi "https://doi.org/10.1007/978-0-387-72430-0_53" @default.
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