Matches in SemOpenAlex for { <https://semopenalex.org/work/W2285291236> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2285291236 endingPage "H625" @default.
- W2285291236 startingPage "H615" @default.
- W2285291236 abstract "This study investigates the developmental changes in myocardial mechanical function and the function of subcellular organelles. Mechanical function was determined at various Ca2+ concentrations ( [Ca2+]0) in the isolated, arterially perfused heart of the fetus (28th day of gestation), newborn (3-5 day old), and adult rabbit. Maximal force of contraction in the fetus (observed at 7.5 mM [Ca2+]0) was significantly less than that in the newborn (observed at 30 mM ( [Ca2+]0), and both the fetus and newborn values were significantly less than that in the adult (observed at 15 mM [Ca2+]0). The myofibrillar content in the fetus and ATPase activity in the fetus and newborn were significantly less than in the adult at pCa 4 and 5 where this enzyme was maximally activated. Both the amount of sarcoplasmic reticulum (SR) and SR Ca2+ uptake per gram of muscle increased with age. Mitochondrial Ca2+ uptake was not observed at pCa more than 6 (physiological range) in all age groups. At pCa less than 6, mitochondrial Ca2+ uptake (per g muscle) in the newborn was significantly greater than in the fetus and adult. Ca2+ uptake by crude homogenate in the newborn was also greater than in the fetus and adult. These data suggest that the age-related change in myocardial contractility is due to the differences in intracellular Ca2+ concentration and myofibrillar content as well as ATPase activity. Intracellular Ca2+ concentration may vary with development depending on the relative capability of Ca2+-releasing system and Ca2+-sequestering system." @default.
- W2285291236 created "2016-06-24" @default.
- W2285291236 creator A5067970141 @default.
- W2285291236 creator A5075020239 @default.
- W2285291236 date "1984-04-01" @default.
- W2285291236 modified "2023-09-24" @default.
- W2285291236 title "Developmental changes in myocardial mechanical function and subcellular organelles" @default.
- W2285291236 doi "https://doi.org/10.1152/ajpheart.1984.246.4.h615" @default.
- W2285291236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6232858" @default.
- W2285291236 hasPublicationYear "1984" @default.
- W2285291236 type Work @default.
- W2285291236 sameAs 2285291236 @default.
- W2285291236 citedByCount "68" @default.
- W2285291236 countsByYear W22852912362016 @default.
- W2285291236 countsByYear W22852912362017 @default.
- W2285291236 countsByYear W22852912362018 @default.
- W2285291236 countsByYear W22852912362019 @default.
- W2285291236 countsByYear W22852912362020 @default.
- W2285291236 crossrefType "journal-article" @default.
- W2285291236 hasAuthorship W2285291236A5067970141 @default.
- W2285291236 hasAuthorship W2285291236A5075020239 @default.
- W2285291236 hasConcept C126322002 @default.
- W2285291236 hasConcept C134018914 @default.
- W2285291236 hasConcept C139966638 @default.
- W2285291236 hasConcept C158617107 @default.
- W2285291236 hasConcept C163415756 @default.
- W2285291236 hasConcept C168240541 @default.
- W2285291236 hasConcept C172680121 @default.
- W2285291236 hasConcept C181199279 @default.
- W2285291236 hasConcept C185592680 @default.
- W2285291236 hasConcept C23265538 @default.
- W2285291236 hasConcept C2779234561 @default.
- W2285291236 hasConcept C28859421 @default.
- W2285291236 hasConcept C39133596 @default.
- W2285291236 hasConcept C519063684 @default.
- W2285291236 hasConcept C54355233 @default.
- W2285291236 hasConcept C55493867 @default.
- W2285291236 hasConcept C71924100 @default.
- W2285291236 hasConcept C7301908 @default.
- W2285291236 hasConcept C79879829 @default.
- W2285291236 hasConcept C86803240 @default.
- W2285291236 hasConceptScore W2285291236C126322002 @default.
- W2285291236 hasConceptScore W2285291236C134018914 @default.
- W2285291236 hasConceptScore W2285291236C139966638 @default.
- W2285291236 hasConceptScore W2285291236C158617107 @default.
- W2285291236 hasConceptScore W2285291236C163415756 @default.
- W2285291236 hasConceptScore W2285291236C168240541 @default.
- W2285291236 hasConceptScore W2285291236C172680121 @default.
- W2285291236 hasConceptScore W2285291236C181199279 @default.
- W2285291236 hasConceptScore W2285291236C185592680 @default.
- W2285291236 hasConceptScore W2285291236C23265538 @default.
- W2285291236 hasConceptScore W2285291236C2779234561 @default.
- W2285291236 hasConceptScore W2285291236C28859421 @default.
- W2285291236 hasConceptScore W2285291236C39133596 @default.
- W2285291236 hasConceptScore W2285291236C519063684 @default.
- W2285291236 hasConceptScore W2285291236C54355233 @default.
- W2285291236 hasConceptScore W2285291236C55493867 @default.
- W2285291236 hasConceptScore W2285291236C71924100 @default.
- W2285291236 hasConceptScore W2285291236C7301908 @default.
- W2285291236 hasConceptScore W2285291236C79879829 @default.
- W2285291236 hasConceptScore W2285291236C86803240 @default.
- W2285291236 hasIssue "4" @default.
- W2285291236 hasLocation W22852912361 @default.
- W2285291236 hasLocation W22852912362 @default.
- W2285291236 hasOpenAccess W2285291236 @default.
- W2285291236 hasPrimaryLocation W22852912361 @default.
- W2285291236 hasRelatedWork W1977573463 @default.
- W2285291236 hasRelatedWork W1997950349 @default.
- W2285291236 hasRelatedWork W2001452769 @default.
- W2285291236 hasRelatedWork W2039848901 @default.
- W2285291236 hasRelatedWork W2044119471 @default.
- W2285291236 hasRelatedWork W2088128251 @default.
- W2285291236 hasRelatedWork W2093742409 @default.
- W2285291236 hasRelatedWork W2285291236 @default.
- W2285291236 hasRelatedWork W2353930155 @default.
- W2285291236 hasRelatedWork W2181734335 @default.
- W2285291236 hasVolume "246" @default.
- W2285291236 isParatext "false" @default.
- W2285291236 isRetracted "false" @default.
- W2285291236 magId "2285291236" @default.
- W2285291236 workType "article" @default.