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• W2285302116 abstract "4178 Background: A better clinical, morphological and molecular characterization to improve outcome prediction for GIST pts in Brazil was our goal. Methods: We reviewed clinical and morphological data from 94 pts with surgically ressected GIST between Jan 1990 and April 2003. DNA samples were isolated from archived tissue and KIT exon 11 and 9 were evaluated for mutation. GIST pts were classified according to the risk into low-, intermediate-, and high-risk based on previously published criteria. Overall (OS) and disease-free survival (DFS) were analyzed. Results: Median age was 56 (9–87); Male/female 38/56; primary tumor sites were stomach (46.8%), small bowel (36.2%) colorectal (8.5%), and mesenteric/peritoneal mass (6.4%). Median tumor size was 8 cm (1.2–52). All cases (n=94) were KIT-positive (CD117). Thirty (34.5%) out of 87 pts in whom the surgery was considered optimal relapsed. Prognostic classification based on tumor size and mitotic index was possible in 82 pts: 20 (23%) were considered low-, 27 (31%) intermediate- and 35 (40%) high-risk. The median follow-up was 25 months. The median DFS and OS could not be reached for low- and intermediate-risk, whereas for high-risk pts were 24 and 33 months, respectively. Note that only 16 (17%) out of 94 pts were treated with Imatinib mesylate. Interestingly, high-risk behavior was correlated with epithelioide subtype (p<0.001), and % of KIT-positive cells (> 75%) (p<0.008). KIT mutation analyzes were possible in tumors from 63 pts (67%). Overall, 37 (58.7%) had KIT activating mutation in exon 11 or 9. The most common type of mutation was in-frame deletion in exon 11 (62.2%). The presence of mutation did not significantly correlate with survival, in contrast with recently published data. Conclusions: The clinical, morphological and molecular characteristics of GIST-pts in Brazil were similar to data reported elsewhere. High-risk pts had significantly worse survival than those with low-risk. Our data suggest that, in addition to tumor size and mitotic index, histologic subtype and % of KIT positivity may be used to predict risk in GIST pts. Additional analysis of exon 13 and 17 will be presented. Supported by Novartis Pharma Brazil. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis" @default.
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• W2285302116 date "2004-07-15" @default.
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• W2285302116 title "Clinical and morphological characterization of GIST patients (pts) in Brazil" @default.
• W2285302116 doi "https://doi.org/10.1200/jco.2004.22.90140.4178" @default.
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