Matches in SemOpenAlex for { <https://semopenalex.org/work/W2285331329> ?p ?o ?g. }
- W2285331329 abstract "Abstract The liver is a unique lymphoid organ whose microenvironment is biased towards tolerance induction. We previously found that a proportion of CD4 + autoreactive recent thymic emigrants (RTEs) retained in the liver after thymic egress and acquired IL-10 producing capability. To investigate the tolerance of these liver persisting CD4 + RTEs in more detail and to study the liver stromal cell types that facilitate the tolerogenic changes in young T cells, the phenotype and function of liver RTEs were further characterized and the impact of liver sinusoidal endothelial cells (LSECs) and Kupffer cells on RTEs were examined using an in vitro co-culture system. More than 70% of CD4 + CD44 hi RTEs in the liver acquired Foxp3 - LAG3 + CD49b − regulatory phenotype and function. But higher ratio of apoptosis with enhanced FasL and Bim expression was also found in these CD4 + liver RTEs when compared to those in the lymph nodes and spleen. LSECs played an important role in RTEs’ acquisition of tolerogenic and regulatory phenotype. These results indicate an important role of liver microenvironment in enforcing peripheral tolerance to CD4 + thymic emigrants against self- and gut-derived antigens." @default.
- W2285331329 created "2016-06-24" @default.
- W2285331329 creator A5013873075 @default.
- W2285331329 creator A5026906414 @default.
- W2285331329 creator A5042060992 @default.
- W2285331329 creator A5065495858 @default.
- W2285331329 creator A5070814503 @default.
- W2285331329 creator A5071672663 @default.
- W2285331329 creator A5071686528 @default.
- W2285331329 creator A5071773009 @default.
- W2285331329 creator A5081514177 @default.
- W2285331329 creator A5083872915 @default.
- W2285331329 creator A5091305811 @default.
- W2285331329 date "2016-01-22" @default.
- W2285331329 modified "2023-10-14" @default.
- W2285331329 title "Liver sinusoidal endothelial cells induce tolerance of autoreactive CD4+ recent thymic emigrants" @default.
- W2285331329 cites W1498929362 @default.
- W2285331329 cites W1573433003 @default.
- W2285331329 cites W1586086237 @default.
- W2285331329 cites W1748089851 @default.
- W2285331329 cites W1970254108 @default.
- W2285331329 cites W1971890973 @default.
- W2285331329 cites W1974781378 @default.
- W2285331329 cites W1977402753 @default.
- W2285331329 cites W1986337007 @default.
- W2285331329 cites W1987735044 @default.
- W2285331329 cites W1990951542 @default.
- W2285331329 cites W2004909098 @default.
- W2285331329 cites W2006214100 @default.
- W2285331329 cites W2009519656 @default.
- W2285331329 cites W2010738373 @default.
- W2285331329 cites W2015610860 @default.
- W2285331329 cites W2020547407 @default.
- W2285331329 cites W2026647673 @default.
- W2285331329 cites W2027581425 @default.
- W2285331329 cites W2036773446 @default.
- W2285331329 cites W2040704107 @default.
- W2285331329 cites W2045444612 @default.
- W2285331329 cites W2050477250 @default.
- W2285331329 cites W2052325775 @default.
- W2285331329 cites W2052877948 @default.
- W2285331329 cites W2054973241 @default.
- W2285331329 cites W2064707212 @default.
- W2285331329 cites W2069220094 @default.
- W2285331329 cites W2070618674 @default.
- W2285331329 cites W2083676790 @default.
- W2285331329 cites W2087668602 @default.
- W2285331329 cites W2087985268 @default.
- W2285331329 cites W2088763689 @default.
- W2285331329 cites W2089004438 @default.
- W2285331329 cites W2090427489 @default.
- W2285331329 cites W2092253488 @default.
- W2285331329 cites W2094809823 @default.
- W2285331329 cites W2116609639 @default.
- W2285331329 cites W2118197531 @default.
- W2285331329 cites W2120488011 @default.
- W2285331329 cites W2126060249 @default.
- W2285331329 cites W2129912620 @default.
- W2285331329 cites W2130877977 @default.
- W2285331329 cites W2136097155 @default.
- W2285331329 cites W2147207812 @default.
- W2285331329 cites W2148106535 @default.
- W2285331329 cites W2148300725 @default.
- W2285331329 cites W2152404236 @default.
- W2285331329 cites W2164872587 @default.
- W2285331329 cites W2166333477 @default.
- W2285331329 cites W2166977320 @default.
- W2285331329 cites W2170567846 @default.
- W2285331329 cites W4248093291 @default.
- W2285331329 doi "https://doi.org/10.1038/srep19861" @default.
- W2285331329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4726350" @default.
- W2285331329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26794038" @default.
- W2285331329 hasPublicationYear "2016" @default.
- W2285331329 type Work @default.
- W2285331329 sameAs 2285331329 @default.
- W2285331329 citedByCount "14" @default.
- W2285331329 countsByYear W22853313292016 @default.
- W2285331329 countsByYear W22853313292017 @default.
- W2285331329 countsByYear W22853313292018 @default.
- W2285331329 countsByYear W22853313292019 @default.
- W2285331329 countsByYear W22853313292020 @default.
- W2285331329 countsByYear W22853313292021 @default.
- W2285331329 countsByYear W22853313292022 @default.
- W2285331329 countsByYear W22853313292023 @default.
- W2285331329 crossrefType "journal-article" @default.
- W2285331329 hasAuthorship W2285331329A5013873075 @default.
- W2285331329 hasAuthorship W2285331329A5026906414 @default.
- W2285331329 hasAuthorship W2285331329A5042060992 @default.
- W2285331329 hasAuthorship W2285331329A5065495858 @default.
- W2285331329 hasAuthorship W2285331329A5070814503 @default.
- W2285331329 hasAuthorship W2285331329A5071672663 @default.
- W2285331329 hasAuthorship W2285331329A5071686528 @default.
- W2285331329 hasAuthorship W2285331329A5071773009 @default.
- W2285331329 hasAuthorship W2285331329A5081514177 @default.
- W2285331329 hasAuthorship W2285331329A5083872915 @default.
- W2285331329 hasAuthorship W2285331329A5091305811 @default.
- W2285331329 hasBestOaLocation W22853313291 @default.
- W2285331329 hasConcept C104317684 @default.
- W2285331329 hasConcept C127716648 @default.
- W2285331329 hasConcept C147483822 @default.