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• W22853414 abstract "In this study, the effect of heparin on three extracellular matrix glycoproteins in porcine aortic endothelial cells was examined. For the extracellular matrix glycoproteins, fibronectin, thrombospondin, and laminin, a concentration range of heparin was applied to endothelial cells and then a variety of biochemical techniques were run to determine that a change in both newly synthesized and expressed protein levels was occurring. In addition, the effect of heparin on cell adhesion molecules was also studied. The results obtained for fibronectin and thrombospondin were compared to results published in the literature on human umbilical vein endothelial cells grown in the presence of growth factors and appeared to be similar. Since there is no published information on heparin's affect of laminin, cycloheximide was also be applied to show that blocking protein synthesis did have an effect on laminin protein levels. Finally, the data that was obtained here may eventually provide important clues to improvin~ the treatment of vessel wall injury in diseased states." @default.
• W22853414 created "2016-06-24" @default.
• W22853414 creator A5086699382 @default.
• W22853414 date "1996-01-01" @default.
• W22853414 modified "2023-09-26" @default.
• W22853414 title "Evidence that heparin affects protein levels of three extracellular matrix glycoproteins" @default.
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