FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2285366293> ?p ?o ?g. }

• W2285366293 endingPage "450" @default.
• W2285366293 startingPage "440" @default.
• W2285366293 abstract "Identification of functional genetic variants and elucidation of their regulatory mechanisms represent significant challenges of the post-genomic era. A poorly understood topic is the involvement of genetic variants in mediating post-transcriptional RNA processing, including alternative splicing. Thus far, little is known about the genomic, evolutionary, and regulatory features of genetically modulated alternative splicing (GMAS). Here, we systematically identified intronic tag variants for genetic modulation of alternative splicing using RNA-seq data specific to cellular compartments. Combined with our previous method that identifies exonic tags for GMAS, this study yielded 622 GMAS exons. We observed that GMAS events are highly cell type independent, indicating that splicing-altering genetic variants could have widespread function across cell types. Interestingly, GMAS genes, exons, and single-nucleotide variants (SNVs) all demonstrated positive selection or accelerated evolution in primates. We predicted that GMAS SNVs often alter binding of splicing factors, with SRSF1 affecting the most GMAS events and demonstrating global allelic binding bias. However, in contrast to their GMAS targets, the predicted splicing factors are more conserved than expected, suggesting that cis-regulatory variation is the major driving force of splicing evolution. Moreover, GMAS-related splicing factors had stronger consensus motifs than expected, consistent with their susceptibility to SNV disruption. Intriguingly, GMAS SNVs in general do not alter the strongest consensus position of the splicing factor motif, except the more than 100 GMAS SNVs in linkage disequilibrium with polymorphisms reported by genome-wide association studies. Our study reports many GMAS events and enables a better understanding of the evolutionary and regulatory features of this phenomenon." @default.
• W2285366293 created "2016-06-24" @default.
• W2285366293 creator A5010336848 @default.
• W2285366293 creator A5023880622 @default.
• W2285366293 creator A5049624856 @default.
• W2285366293 creator A5061238910 @default.
• W2285366293 creator A5065793559 @default.
• W2285366293 creator A5068324646 @default.
• W2285366293 date "2016-02-17" @default.
• W2285366293 modified "2023-10-14" @default.
• W2285366293 title "Alternative splicing modulated by genetic variants demonstrates accelerated evolution regulated by highly conserved proteins" @default.
• W2285366293 cites W1829675031 @default.
• W2285366293 cites W1963905877 @default.
• W2285366293 cites W1968048466 @default.
• W2285366293 cites W1968569455 @default.
• W2285366293 cites W1968886567 @default.
• W2285366293 cites W1977957409 @default.
• W2285366293 cites W1982516282 @default.
• W2285366293 cites W1987754412 @default.
• W2285366293 cites W1995224771 @default.
• W2285366293 cites W1997476591 @default.
• W2285366293 cites W2019097736 @default.
• W2285366293 cites W2025253353 @default.
• W2285366293 cites W2025943989 @default.
• W2285366293 cites W2029979788 @default.
• W2285366293 cites W2062872865 @default.
• W2285366293 cites W2068351003 @default.
• W2285366293 cites W2068851900 @default.
• W2285366293 cites W2074472459 @default.
• W2285366293 cites W2088338354 @default.
• W2285366293 cites W2089290332 @default.
• W2285366293 cites W2092645079 @default.
• W2285366293 cites W2092756750 @default.
• W2285366293 cites W2094608047 @default.
• W2285366293 cites W2095998476 @default.
• W2285366293 cites W2096791516 @default.
• W2285366293 cites W2098824600 @default.
• W2285366293 cites W2103999254 @default.
• W2285366293 cites W2105694586 @default.
• W2285366293 cites W2108246734 @default.
• W2285366293 cites W2114880905 @default.
• W2285366293 cites W2115820057 @default.
• W2285366293 cites W2116868464 @default.
• W2285366293 cites W2118551099 @default.
• W2285366293 cites W2136549268 @default.
• W2285366293 cites W2138431129 @default.
• W2285366293 cites W2140784970 @default.
• W2285366293 cites W2141602707 @default.
• W2285366293 cites W2145191876 @default.
• W2285366293 cites W2151462466 @default.
• W2285366293 cites W2154539700 @default.
• W2285366293 cites W2156799643 @default.
• W2285366293 cites W2159418321 @default.
• W2285366293 cites W2166810745 @default.
• W2285366293 cites W2167164394 @default.
• W2285366293 cites W2171405631 @default.
• W2285366293 cites W2259938310 @default.
• W2285366293 cites W4231311503 @default.
• W2285366293 doi "https://doi.org/10.1101/gr.193359.115" @default.
• W2285366293 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4817768" @default.
• W2285366293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26888265" @default.
• W2285366293 hasPublicationYear "2016" @default.
• W2285366293 type Work @default.
• W2285366293 sameAs 2285366293 @default.
• W2285366293 citedByCount "43" @default.
• W2285366293 countsByYear W22853662932016 @default.
• W2285366293 countsByYear W22853662932017 @default.
• W2285366293 countsByYear W22853662932018 @default.
• W2285366293 countsByYear W22853662932019 @default.
• W2285366293 countsByYear W22853662932020 @default.
• W2285366293 countsByYear W22853662932021 @default.
• W2285366293 countsByYear W22853662932022 @default.
• W2285366293 countsByYear W22853662932023 @default.
• W2285366293 crossrefType "journal-article" @default.
• W2285366293 hasAuthorship W2285366293A5010336848 @default.
• W2285366293 hasAuthorship W2285366293A5023880622 @default.
• W2285366293 hasAuthorship W2285366293A5049624856 @default.
• W2285366293 hasAuthorship W2285366293A5061238910 @default.
• W2285366293 hasAuthorship W2285366293A5065793559 @default.
• W2285366293 hasAuthorship W2285366293A5068324646 @default.
• W2285366293 hasBestOaLocation W22853662931 @default.
• W2285366293 hasConcept C104317684 @default.
• W2285366293 hasConcept C194583182 @default.
• W2285366293 hasConcept C36823959 @default.
• W2285366293 hasConcept C54355233 @default.
• W2285366293 hasConcept C54458228 @default.
• W2285366293 hasConcept C67705224 @default.
• W2285366293 hasConcept C70721500 @default.
• W2285366293 hasConcept C78458016 @default.
• W2285366293 hasConcept C86803240 @default.
• W2285366293 hasConceptScore W2285366293C104317684 @default.
• W2285366293 hasConceptScore W2285366293C194583182 @default.
• W2285366293 hasConceptScore W2285366293C36823959 @default.
• W2285366293 hasConceptScore W2285366293C54355233 @default.
• W2285366293 hasConceptScore W2285366293C54458228 @default.
• W2285366293 hasConceptScore W2285366293C67705224 @default.
• W2285366293 hasConceptScore W2285366293C70721500 @default.
• W2285366293 hasConceptScore W2285366293C78458016 @default.

• next