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- W2285409828 abstract "Telomere-Associated Proteins in Arabidopsis thaliana. (May 2008) Yulia V. Surovtseva, B.S., Novosibirsk State University, Russia Chair of Advisory Committee: Dr. Dorothy E. Shippen Telomeres comprise the physical ends of chromosomes. Essential functions of telomeres include protecting the terminus from being recognized as a DNA doublestrand break and facilitating the complete replication of the physical end of the DNA. Telomere functions are mediated by a large array of telomere-associated proteins. Mutations in telomere-related genes cause immediate telomere dysfunction, activation of DNA damage response, and accumulation of end-to-end chromosome fusions. In addition, changes in telomere complex composition may affect the ability of the telomerase enzyme to maintain telomeres in vivo. Here, we describe the characterization of telomere-associated proteins in the flowering plant, Arabidopsis thaliana. Using a bioinformatics approach, we identified twelve proteins with sequence similarity to vertebrate duplex telomere DNA binding proteins TRF1 and TRF2. We showed that, like their vertebrate counterparts, some of the Arabidopsis TRFL (TRF-LIKE) proteins can homodimerize and bind telomeric DNA in vitro, indicating that Arabidopsis encodes a large family of double-strand telomeric DNA binding proteins. We have also characterized three Arabidopsis POT1 proteins whose homologs in yeast and vertebrates associate with the single-stranded portion of telomeric DNA. Unexpectedly, we found that unlike POT1 protein in other organisms, Arabidopsis AtPOT1a protein associates with telomeres only in the S phase of the cell" @default.
- W2285409828 created "2016-06-24" @default.
- W2285409828 creator A5005079725 @default.
- W2285409828 date "2008-01-01" @default.
- W2285409828 modified "2023-09-23" @default.
- W2285409828 title "Telomere-associated proteins in Arabidopsis thaliana" @default.
- W2285409828 cites W1215835221 @default.
- W2285409828 cites W147880112 @default.
- W2285409828 cites W1484414970 @default.
- W2285409828 cites W1485522487 @default.
- W2285409828 cites W1495746426 @default.
- W2285409828 cites W1508472068 @default.
- W2285409828 cites W1538654663 @default.
- W2285409828 cites W1541877559 @default.
- W2285409828 cites W1543500873 @default.
- W2285409828 cites W1571464398 @default.
- W2285409828 cites W1595594899 @default.
- W2285409828 cites W1829553711 @default.
- W2285409828 cites W1863149810 @default.
- W2285409828 cites W1870159184 @default.
- W2285409828 cites W188865548 @default.
- W2285409828 cites W1932735166 @default.
- W2285409828 cites W1943069336 @default.
- W2285409828 cites W1948628402 @default.
- W2285409828 cites W1956123188 @default.
- W2285409828 cites W1958533176 @default.
- W2285409828 cites W1963881770 @default.
- W2285409828 cites W1964228845 @default.
- W2285409828 cites W1964393554 @default.
- W2285409828 cites W1965019589 @default.
- W2285409828 cites W1965505004 @default.
- W2285409828 cites W1966149222 @default.
- W2285409828 cites W1966724584 @default.
- W2285409828 cites W1967017947 @default.
- W2285409828 cites W1969889044 @default.
- W2285409828 cites W1970526829 @default.
- W2285409828 cites W1970604907 @default.
- W2285409828 cites W1971358935 @default.
- W2285409828 cites W1971361148 @default.
- W2285409828 cites W1971458488 @default.
- W2285409828 cites W1971503458 @default.
- W2285409828 cites W1972187528 @default.
- W2285409828 cites W1972655555 @default.
- W2285409828 cites W1973544851 @default.
- W2285409828 cites W1976505161 @default.
- W2285409828 cites W1977172248 @default.
- W2285409828 cites W1977437036 @default.
- W2285409828 cites W1977780474 @default.
- W2285409828 cites W1977871027 @default.
- W2285409828 cites W1978002329 @default.
- W2285409828 cites W1979181676 @default.
- W2285409828 cites W1979657436 @default.
- W2285409828 cites W1981682709 @default.
- W2285409828 cites W1981936717 @default.
- W2285409828 cites W1982199027 @default.
- W2285409828 cites W1983546805 @default.
- W2285409828 cites W1983673827 @default.
- W2285409828 cites W1984765930 @default.
- W2285409828 cites W1984909864 @default.
- W2285409828 cites W1985096875 @default.
- W2285409828 cites W1985910710 @default.
- W2285409828 cites W1985964699 @default.
- W2285409828 cites W1986425636 @default.
- W2285409828 cites W1986659195 @default.
- W2285409828 cites W1987223270 @default.
- W2285409828 cites W1987643363 @default.
- W2285409828 cites W1988669405 @default.
- W2285409828 cites W1989039494 @default.
- W2285409828 cites W1989117430 @default.
- W2285409828 cites W1989343323 @default.
- W2285409828 cites W1989635874 @default.
- W2285409828 cites W1990294201 @default.
- W2285409828 cites W1990517476 @default.
- W2285409828 cites W1990556626 @default.
- W2285409828 cites W1992350296 @default.
- W2285409828 cites W1992842240 @default.
- W2285409828 cites W1992851153 @default.
- W2285409828 cites W1994277807 @default.
- W2285409828 cites W1995463612 @default.
- W2285409828 cites W1995816981 @default.
- W2285409828 cites W1997141870 @default.
- W2285409828 cites W1997316701 @default.
- W2285409828 cites W1999086372 @default.
- W2285409828 cites W1999307044 @default.
- W2285409828 cites W1999649555 @default.
- W2285409828 cites W1999743187 @default.
- W2285409828 cites W1999821301 @default.
- W2285409828 cites W2001828972 @default.
- W2285409828 cites W2003170504 @default.
- W2285409828 cites W2003411878 @default.
- W2285409828 cites W2003446723 @default.
- W2285409828 cites W2003798106 @default.
- W2285409828 cites W2004106262 @default.
- W2285409828 cites W2004173334 @default.
- W2285409828 cites W2004314923 @default.
- W2285409828 cites W2004561527 @default.
- W2285409828 cites W2004589024 @default.
- W2285409828 cites W2005576986 @default.
- W2285409828 cites W2006979086 @default.
- W2285409828 cites W2007452601 @default.