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- W2285443764 abstract "Objective:To investigate the effects of ethanol extract of cochinchina momordica seed(CMSEE)on the invasion and metastasis of melanoma B16 cells in vitro and in vivo,as well as its probable mechanism.Methods:Effects of CMSEE(20,25 and 30 μg/mL)on the invasion and metastasis of B16 cells were detected by scratch assay and Transwell assay.The transcriptional levels of matrix metalloproteinases(MMP)-9 and MMP-2 in B16 cells treated with different doses of CMSEE(20,25 and 30 μg/mL)for various times(0,6,12,24,36 and 48 h)were detected by RT-PCR.Expressions of MMP-2,MMP-9,tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 proteins in B16 cells treated with CMSEE were analyzed by Western blotting.The B16-implanted mouse model was established,and the metastasis and invasion of B16-implanted tumors were observed after treatment with CMSEE.Results:After treatment by 20-30 μg/mL CMSEE,the diameters of scratch became broader than the control group(P0.05),and B16 cells through the Transwell chambers were decreased significantly in a dose-dependent manner(P0.05).CMSEE could down-regulate the expression levels of MMP-9 and MMP-2 mRNAs and proteins in a dose-dependent manner.Expressions of TIMP-1 and TIMP-2 proteins in B16 cells treated with CMSEE did not changed.CMSEE effectively inhibited the metastasis and invasion of B16-implanted tumors in the mice.Conclusion:CMSEE could inhibit the invasion and metastasis of melanoma B16 cells in vitro and in vivo,and the mechanism may be related with down-regulating the expressions of MMP-2 and MMP-9 mRNAs and proteins." @default.
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- W2285443764 date "2010-01-01" @default.
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- W2285443764 title "Effects of ethanol extract of cochinchina momordica seed on invasion and metastasis of mouse melanoma B16 cells in vitro and in vivo" @default.
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