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• W2285514562 abstract "Abstract Steroidal glycoalkaloids (SGAs) are cholesterol-derived molecules produced by solanaceous species. They contribute to pathogen defence but are toxic to humans and considered as anti-nutritional compounds. Here we show that GLYCOALKALOID METABOLISM 9 ( GAME9 ), an APETALA2/Ethylene Response Factor, related to regulators of alkaloid production in tobacco and Catharanthus roseus , controls SGA biosynthesis. GAME9 knockdown and overexpression in tomato and potato alters expression of SGAs and upstream mevalonate pathway genes including the cholesterol biosynthesis gene STEROL SIDE CHAIN REDUCTASE 2 ( SSR2 ). Levels of SGAs, C24-alkylsterols and the upstream mevalonate and cholesterol pathways intermediates are modified in these plants. Δ(7)-STEROL-C5(6)-DESATURASE (C5-SD) in the hitherto unresolved cholesterol pathway is a direct target of GAME9. Transactivation and promoter-binding assays show that GAME9 exerts its activity either directly or cooperatively with the SlMYC2 transcription factor as in the case of the C5-SD gene promoter. Our findings provide insight into the regulation of SGA biosynthesis and means for manipulating these metabolites in crops." @default.
• W2285514562 created "2016-06-24" @default.
• W2285514562 creator A5007176844 @default.
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• W2285514562 date "2016-02-15" @default.
• W2285514562 modified "2023-10-16" @default.
• W2285514562 title "GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway" @default.
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• W2285514562 doi "https://doi.org/10.1038/ncomms10654" @default.
• W2285514562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4756317" @default.
• W2285514562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26876023" @default.
• W2285514562 hasPublicationYear "2016" @default.
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