FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2285635103> ?p ?o ?g. }

• W2285635103 endingPage "3016" @default.
• W2285635103 startingPage "3009" @default.
• W2285635103 abstract "Shikonin, which is a major ingredient of the traditional Chinese herb Lithospermum erythrorhizon, possesses various biological functions, including antimicrobial, anti-inflammatory, and antitumor activities. The present study aimed to determine the molecular mechanisms underlying the effects of shikonin on HaCaT cell apoptosis. Treatment with shikonin significantly inhibited the viability of HaCaT cells in a dose‑ and time‑dependent manner, and promoted cell cycle arrest at G0/G1 phase and apoptosis. In addition, shikonin treatment reduced the mitochondrial membrane potential and induced reactive oxygen species generation. The results of a western blot analysis demonstrated that shikonin significantly activated caspase 3 expression, downregulated B‑cell lymphoma 2 (Bcl‑2) expression, and upregulated Bcl‑2‑associated X protein and Bcl‑2 homologous antagonist killer expression in a dose‑dependent manner in HaCaT cells. Furthermore, shikonin decreased extracellular signal‑regulated kinase (Erk) and Akt phosphorylation. These results indicated that shikonin may exert its anti‑proliferative effects by inducing apoptosis via activation of the mitochondrial signaling pathway and inactivation of the Akt and Erk pathways in HaCaT cells. Therefore, the present study suggested that shikonin may have potential as a component of therapeutic strategies for the treatment of skin diseases." @default.
• W2285635103 created "2016-06-24" @default.
• W2285635103 creator A5009714107 @default.
• W2285635103 creator A5019486721 @default.
• W2285635103 creator A5023346134 @default.
• W2285635103 creator A5032917190 @default.
• W2285635103 creator A5043528779 @default.
• W2285635103 creator A5068284208 @default.
• W2285635103 creator A5069032292 @default.
• W2285635103 creator A5078102982 @default.
• W2285635103 creator A5080531831 @default.
• W2285635103 creator A5083411020 @default.
• W2285635103 date "2016-02-19" @default.
• W2285635103 modified "2023-10-12" @default.
• W2285635103 title "Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways" @default.
• W2285635103 cites W1570689006 @default.
• W2285635103 cites W1987751343 @default.
• W2285635103 cites W1990359801 @default.
• W2285635103 cites W1996914764 @default.
• W2285635103 cites W1998200945 @default.
• W2285635103 cites W2000051219 @default.
• W2285635103 cites W2001177851 @default.
• W2285635103 cites W2006944445 @default.
• W2285635103 cites W2008757142 @default.
• W2285635103 cites W2024640050 @default.
• W2285635103 cites W2029128188 @default.
• W2285635103 cites W2040150857 @default.
• W2285635103 cites W2041095149 @default.
• W2285635103 cites W2049856484 @default.
• W2285635103 cites W2051524616 @default.
• W2285635103 cites W2064096260 @default.
• W2285635103 cites W2079931546 @default.
• W2285635103 cites W2081024827 @default.
• W2285635103 cites W2089769997 @default.
• W2285635103 cites W2089994718 @default.
• W2285635103 cites W2090535286 @default.
• W2285635103 cites W2097088463 @default.
• W2285635103 cites W2140967934 @default.
• W2285635103 cites W2149335113 @default.
• W2285635103 cites W2151501496 @default.
• W2285635103 cites W2165805342 @default.
• W2285635103 cites W2410679962 @default.
• W2285635103 cites W288646517 @default.
• W2285635103 cites W2171163250 @default.
• W2285635103 doi "https://doi.org/10.3892/mmr.2016.4917" @default.
• W2285635103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4805065" @default.
• W2285635103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26935874" @default.
• W2285635103 hasPublicationYear "2016" @default.
• W2285635103 type Work @default.
• W2285635103 sameAs 2285635103 @default.
• W2285635103 citedByCount "13" @default.
• W2285635103 countsByYear W22856351032016 @default.
• W2285635103 countsByYear W22856351032017 @default.
• W2285635103 countsByYear W22856351032018 @default.
• W2285635103 countsByYear W22856351032019 @default.
• W2285635103 countsByYear W22856351032020 @default.
• W2285635103 countsByYear W22856351032021 @default.
• W2285635103 countsByYear W22856351032022 @default.
• W2285635103 countsByYear W22856351032023 @default.
• W2285635103 crossrefType "journal-article" @default.
• W2285635103 hasAuthorship W2285635103A5009714107 @default.
• W2285635103 hasAuthorship W2285635103A5019486721 @default.
• W2285635103 hasAuthorship W2285635103A5023346134 @default.
• W2285635103 hasAuthorship W2285635103A5032917190 @default.
• W2285635103 hasAuthorship W2285635103A5043528779 @default.
• W2285635103 hasAuthorship W2285635103A5068284208 @default.
• W2285635103 hasAuthorship W2285635103A5069032292 @default.
• W2285635103 hasAuthorship W2285635103A5078102982 @default.
• W2285635103 hasAuthorship W2285635103A5080531831 @default.
• W2285635103 hasAuthorship W2285635103A5083411020 @default.
• W2285635103 hasBestOaLocation W22856351031 @default.
• W2285635103 hasConcept C118995209 @default.
• W2285635103 hasConcept C184235292 @default.
• W2285635103 hasConcept C185592680 @default.
• W2285635103 hasConcept C190283241 @default.
• W2285635103 hasConcept C29537977 @default.
• W2285635103 hasConcept C502942594 @default.
• W2285635103 hasConcept C53227056 @default.
• W2285635103 hasConcept C54355233 @default.
• W2285635103 hasConcept C55493867 @default.
• W2285635103 hasConcept C57074206 @default.
• W2285635103 hasConcept C62112901 @default.
• W2285635103 hasConcept C62478195 @default.
• W2285635103 hasConcept C75217442 @default.
• W2285635103 hasConcept C81885089 @default.
• W2285635103 hasConcept C86554907 @default.
• W2285635103 hasConcept C86803240 @default.
• W2285635103 hasConcept C95444343 @default.
• W2285635103 hasConceptScore W2285635103C118995209 @default.
• W2285635103 hasConceptScore W2285635103C184235292 @default.
• W2285635103 hasConceptScore W2285635103C185592680 @default.
• W2285635103 hasConceptScore W2285635103C190283241 @default.
• W2285635103 hasConceptScore W2285635103C29537977 @default.
• W2285635103 hasConceptScore W2285635103C502942594 @default.
• W2285635103 hasConceptScore W2285635103C53227056 @default.
• W2285635103 hasConceptScore W2285635103C54355233 @default.
• W2285635103 hasConceptScore W2285635103C55493867 @default.
• W2285635103 hasConceptScore W2285635103C57074206 @default.

• next