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- W2285655138 abstract "1116 Objectives: We are often attracted by novel visual stimuli, even in the absence of narrative meaning. In order to understand the underlying mechanisms, we examined whether the dopaminergic system is involved in attention to novel visual stimuli in humans. A videotaped depiction of individuals using drug paraphernalia and cocaine served as the novel visual stimulus for drug-naive subjects. Methods: Fifteen young adults (age: 30.8 ± 9.1) underwent two bolus-injection [11C]raclopride PET scans while viewing videotapes of natural (Scan 1) and drug-usage (Scan 2) scenes. Subjects were cognitively intact and reported no history of drug abuse. Binding potential (BP) maps were constructed using the bolus-plus-infusion transformation method (Kuwabara, et al., 2002). Each BP map was spatially normalized to a standard brain and smoothed with a 10 mm Gaussian kernel using SPM2. BP maps of Scan 1 were contrasted to BP maps of Scan 2 using SPM2 to identify regions showing significant decreases in BP. Results: The SPM analysis revealed one cluster of decreased BP in right anterior putamen at a p Research Support (if any): AA12839; MH078175; K24 DA00412 (DFW)" @default.
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- W2285655138 date "2007-05-01" @default.
- W2285655138 modified "2023-09-22" @default.
- W2285655138 title "Involvement of dopaminergic system in attention to novel visual stimuli as revealed by [11C]raclopride PET scans" @default.
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