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• W2285691134 abstract "Significance It has long been thought that sleep and mood are intimately connected in humans, but at present there are no known molecular links. We identified rare variants in the PERIOD3 gene in persons with both altered sleep behavior and features of seasonal affective disorder. We show that these variants recapitulate circadian and mood phenotypes in mouse models. Although we were not able to test mood in fruit flies, we did uncover a sleep trait similar to that seen in humans in flies carrying the human variants. Our molecular studies reveal that the variants led to less stable PER3 protein and reduced the stabilizing effect of PER3 on PER1/PER2, providing a mechanistic explanation for the circadian trait." @default.
• W2285691134 created "2016-06-24" @default.
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• W2285691134 date "2016-02-22" @default.
• W2285691134 modified "2023-10-17" @default.
• W2285691134 title "A <i>PERIOD3</i> variant causes a circadian phenotype and is associated with a seasonal mood trait" @default.
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• W2285691134 doi "https://doi.org/10.1073/pnas.1600039113" @default.
• W2285691134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4801303" @default.
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• W2285691134 hasPublicationYear "2016" @default.
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