Matches in SemOpenAlex for { <https://semopenalex.org/work/W2285723607> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2285723607 endingPage "9" @default.
- W2285723607 startingPage "1025" @default.
- W2285723607 abstract "Hexacarbon compounds are neurotoxic to man and animals. These substances also inhibit various enzymes in vitro, including acetylcholinesterase. Since some cholinesterase inhibitors alter nociception we determined the effect of acute ip administration of 2,5-hexanedione on nociception in female Wistar rats (75-90 days old, 170-200 g; 15-17 rats in each group) using a tail-flick apparatus. The rats were injected ip with vehicle solution (120 mM NaCl containing 10 mM potassium phosphate buffer, pH 7.2) and 200, 400 or 800 mg/kg of 2,5-hexanedione in a volume of 1 ml/kg body weight. Tail-flick latencies were obtained 10, 30, 60 and 90 min after drug administration. All doses of 2,5-hexanedione caused antinociception (P less than 0.001) but the appearance and duration of the analgesia varied according to the dose of the drug. The highest dose tested (800 mg/kg) caused analgesia from 10 to 60 min, 400 mg/kg caused analgesia at 30 and 60 min, and 200 mg/kg produced antinociception only at 60 min after drug injection (P less than 0.05 for all the above comparisons). These results suggest that 2,5-hexanedione induces antinociception in rats. Whether this effect is mediated by a cholinergic mechanism is under investigation." @default.
- W2285723607 created "2016-06-24" @default.
- W2285723607 creator A5055590270 @default.
- W2285723607 creator A5077801380 @default.
- W2285723607 creator A5084222587 @default.
- W2285723607 date "1991-01-01" @default.
- W2285723607 modified "2023-09-23" @default.
- W2285723607 title "Effect of acute administration of 2,5-hexanedione on nociception in rats." @default.
- W2285723607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1797254" @default.
- W2285723607 hasPublicationYear "1991" @default.
- W2285723607 type Work @default.
- W2285723607 sameAs 2285723607 @default.
- W2285723607 citedByCount "0" @default.
- W2285723607 crossrefType "journal-article" @default.
- W2285723607 hasAuthorship W2285723607A5055590270 @default.
- W2285723607 hasAuthorship W2285723607A5077801380 @default.
- W2285723607 hasAuthorship W2285723607A5084222587 @default.
- W2285723607 hasConcept C134018914 @default.
- W2285723607 hasConcept C15490471 @default.
- W2285723607 hasConcept C170493617 @default.
- W2285723607 hasConcept C181199279 @default.
- W2285723607 hasConcept C185592680 @default.
- W2285723607 hasConcept C22885893 @default.
- W2285723607 hasConcept C2778816929 @default.
- W2285723607 hasConcept C2780820201 @default.
- W2285723607 hasConcept C31896038 @default.
- W2285723607 hasConcept C52396799 @default.
- W2285723607 hasConcept C55493867 @default.
- W2285723607 hasConcept C71924100 @default.
- W2285723607 hasConcept C98274493 @default.
- W2285723607 hasConceptScore W2285723607C134018914 @default.
- W2285723607 hasConceptScore W2285723607C15490471 @default.
- W2285723607 hasConceptScore W2285723607C170493617 @default.
- W2285723607 hasConceptScore W2285723607C181199279 @default.
- W2285723607 hasConceptScore W2285723607C185592680 @default.
- W2285723607 hasConceptScore W2285723607C22885893 @default.
- W2285723607 hasConceptScore W2285723607C2778816929 @default.
- W2285723607 hasConceptScore W2285723607C2780820201 @default.
- W2285723607 hasConceptScore W2285723607C31896038 @default.
- W2285723607 hasConceptScore W2285723607C52396799 @default.
- W2285723607 hasConceptScore W2285723607C55493867 @default.
- W2285723607 hasConceptScore W2285723607C71924100 @default.
- W2285723607 hasConceptScore W2285723607C98274493 @default.
- W2285723607 hasIssue "10" @default.
- W2285723607 hasLocation W22857236071 @default.
- W2285723607 hasOpenAccess W2285723607 @default.
- W2285723607 hasPrimaryLocation W22857236071 @default.
- W2285723607 hasRelatedWork W196280710 @default.
- W2285723607 hasRelatedWork W1986077056 @default.
- W2285723607 hasRelatedWork W2046380272 @default.
- W2285723607 hasRelatedWork W2046385504 @default.
- W2285723607 hasRelatedWork W2169923433 @default.
- W2285723607 hasRelatedWork W2319776891 @default.
- W2285723607 hasRelatedWork W252950325 @default.
- W2285723607 hasRelatedWork W2792273756 @default.
- W2285723607 hasRelatedWork W2912142776 @default.
- W2285723607 hasRelatedWork W3023426355 @default.
- W2285723607 hasVolume "24" @default.
- W2285723607 isParatext "false" @default.
- W2285723607 isRetracted "false" @default.
- W2285723607 magId "2285723607" @default.
- W2285723607 workType "article" @default.