Matches in SemOpenAlex for { <https://semopenalex.org/work/W2285751922> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2285751922 abstract "A specific, fast and sensitive high performance liquid chromatography (HPLC) coupled to atmospheric pressure photoionization (APPI) tandem mass spectrometric (LC-MS/MS) assay was developed for the determination of cyproterone (CYP) acetate (CAS 427-51-0) in human plasma. The retention times were 3.26 and 2.90 min for CYP acetate and its internal standard (I. S.) finasteride (FIN), respectively. The overall mean recovery, using liquid/liquid extraction, was found to be 109.0, 107.7 and 100.3%, for low, medium and high concentrations, respectively. Calibration curves were linear in the concentration range of 0.1-50.0 ng/ml, and the lower limit of quantification (LLOQ) was 0.1 ng/ml. The LLOQ, 0.1 ng/ml, was sensitive enough for detecting terminal phase concentrations of the drug. Inter-batch precision of the method ranged from 2.2 to 5.55%, while Inter-batch accuracy ranged from 95.5 to 100.0%. Intra-batch precision ranged from 1.8 to 5.6%, while Intra-batch accuracy ranged from 92.0 to 99.4% at concentrations of 0.3 ng/ml, 20.0 and 40.0 ng/ml. The developed method was applied to a bioequivalenc study of CYP acetate in a group of 44 female volunteers at a single oral dose of a 2 mg tablet, in a combination of ethinylestradiol/CYP acetate (0.25/2 mg). The plasma concentration of CYP acetate did not differ significantly after administration of both formulations (test formulation and the reference one). The geometric mean and respective 90% CI of CYP acetate test/reference percent ratios were 90.66% (84.39-97.40%) for Cmax and 96.20% (90.45-102.33%) for AUC0-t." @default.
- W2285751922 created "2016-06-24" @default.
- W2285751922 creator A5022315055 @default.
- W2285751922 creator A5025848362 @default.
- W2285751922 creator A5034714478 @default.
- W2285751922 creator A5040533030 @default.
- W2285751922 creator A5042119652 @default.
- W2285751922 creator A5070978635 @default.
- W2285751922 creator A5071899760 @default.
- W2285751922 creator A5089119280 @default.
- W2285751922 date "2011-12-13" @default.
- W2285751922 modified "2023-10-01" @default.
- W2285751922 title "Cyproterone Acetate Quantification in Human Plasma by High-performance Liquid Chromatography Coupled to Atmospheric Pressure Photoionization Tandem Mass Spectrometry" @default.
- W2285751922 doi "https://doi.org/10.1055/s-0031-1296405" @default.
- W2285751922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19728560" @default.
- W2285751922 hasPublicationYear "2011" @default.
- W2285751922 type Work @default.
- W2285751922 sameAs 2285751922 @default.
- W2285751922 citedByCount "0" @default.
- W2285751922 crossrefType "journal-article" @default.
- W2285751922 hasAuthorship W2285751922A5022315055 @default.
- W2285751922 hasAuthorship W2285751922A5025848362 @default.
- W2285751922 hasAuthorship W2285751922A5034714478 @default.
- W2285751922 hasAuthorship W2285751922A5040533030 @default.
- W2285751922 hasAuthorship W2285751922A5042119652 @default.
- W2285751922 hasAuthorship W2285751922A5070978635 @default.
- W2285751922 hasAuthorship W2285751922A5071899760 @default.
- W2285751922 hasAuthorship W2285751922A5089119280 @default.
- W2285751922 hasConcept C112705442 @default.
- W2285751922 hasConcept C162356407 @default.
- W2285751922 hasConcept C179998833 @default.
- W2285751922 hasConcept C185592680 @default.
- W2285751922 hasConcept C2776306840 @default.
- W2285751922 hasConcept C2777130120 @default.
- W2285751922 hasConcept C2777155358 @default.
- W2285751922 hasConcept C2777911890 @default.
- W2285751922 hasConcept C2779858419 @default.
- W2285751922 hasConcept C31827203 @default.
- W2285751922 hasConcept C43617362 @default.
- W2285751922 hasConcept C4725764 @default.
- W2285751922 hasConcept C55493867 @default.
- W2285751922 hasConcept C64489805 @default.
- W2285751922 hasConcept C71315377 @default.
- W2285751922 hasConcept C71924100 @default.
- W2285751922 hasConcept C98274493 @default.
- W2285751922 hasConceptScore W2285751922C112705442 @default.
- W2285751922 hasConceptScore W2285751922C162356407 @default.
- W2285751922 hasConceptScore W2285751922C179998833 @default.
- W2285751922 hasConceptScore W2285751922C185592680 @default.
- W2285751922 hasConceptScore W2285751922C2776306840 @default.
- W2285751922 hasConceptScore W2285751922C2777130120 @default.
- W2285751922 hasConceptScore W2285751922C2777155358 @default.
- W2285751922 hasConceptScore W2285751922C2777911890 @default.
- W2285751922 hasConceptScore W2285751922C2779858419 @default.
- W2285751922 hasConceptScore W2285751922C31827203 @default.
- W2285751922 hasConceptScore W2285751922C43617362 @default.
- W2285751922 hasConceptScore W2285751922C4725764 @default.
- W2285751922 hasConceptScore W2285751922C55493867 @default.
- W2285751922 hasConceptScore W2285751922C64489805 @default.
- W2285751922 hasConceptScore W2285751922C71315377 @default.
- W2285751922 hasConceptScore W2285751922C71924100 @default.
- W2285751922 hasConceptScore W2285751922C98274493 @default.
- W2285751922 hasLocation W22857519221 @default.
- W2285751922 hasLocation W22857519222 @default.
- W2285751922 hasOpenAccess W2285751922 @default.
- W2285751922 hasPrimaryLocation W22857519221 @default.
- W2285751922 hasRelatedWork W1971890337 @default.
- W2285751922 hasRelatedWork W1980726960 @default.
- W2285751922 hasRelatedWork W2015498980 @default.
- W2285751922 hasRelatedWork W2019528070 @default.
- W2285751922 hasRelatedWork W2020105846 @default.
- W2285751922 hasRelatedWork W2022729215 @default.
- W2285751922 hasRelatedWork W2032837052 @default.
- W2285751922 hasRelatedWork W2033300139 @default.
- W2285751922 hasRelatedWork W2033519520 @default.
- W2285751922 hasRelatedWork W2055164598 @default.
- W2285751922 hasRelatedWork W2061550256 @default.
- W2285751922 hasRelatedWork W2064628656 @default.
- W2285751922 hasRelatedWork W2075414744 @default.
- W2285751922 hasRelatedWork W2092275926 @default.
- W2285751922 hasRelatedWork W2129241285 @default.
- W2285751922 hasRelatedWork W2136601641 @default.
- W2285751922 hasRelatedWork W2138875443 @default.
- W2285751922 hasRelatedWork W2157723481 @default.
- W2285751922 hasRelatedWork W2323390642 @default.
- W2285751922 hasRelatedWork W2327357965 @default.
- W2285751922 isParatext "false" @default.
- W2285751922 isRetracted "false" @default.
- W2285751922 magId "2285751922" @default.
- W2285751922 workType "article" @default.