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• W2285830144 endingPage "814" @default.
• W2285830144 startingPage "810" @default.
• W2285830144 abstract "To investigate whether pituitary desensitization with the gonadotropin-releasing hormone agonist (GnRH-a), buserelin acetate, before the administration of human menopausal gonadotropin (hMG) for ovarian stimulation in in vitro fertilization (IVF) is superior to the simultaneous administration of both hormones at the beginning of the treatment cycle. Prospective randomized study. Ninty-one patients having their first attempt at IVF. Patients in group 1 (long protocol) were administered subcutaneous (SC) buserelin acetate 200 μg/d from day 1 of the menstrual cycle, and hMG was started only after pituitary desensitization had been achieved at least 14 days later. Patients in group 2 (short protocol) were administered SC buserelin acetate 200 μg/d from day 2 and the same dose of hMG used in the long protocol from day 3 of the menstrual cycle. The median total amount of hMG required in both groups was comparable. There were significantly more follicles (P = 0.0001), oocytes (P = 0.0008), fertilized oocytes (P = 0.0001), and cleaved embryos (P = 0.0001), and a higher fertilization rate (P = 0.0047) in patients in group 1. The pregnancy rates per initiated cycle and per embryo transfer were 19.57% and 25.71% in group 1 compared with 8.89% and 16.67% in group 2. The long protocol is superior in terms of significantly greater follicular recruitment, oocyte recovery and fertilization rates, and significantly greater number of embryos available for transfer. In general, it is the preferred method when GnRH-a are used for ovarian stimulation in IVF." @default.
• W2285830144 created "2016-06-24" @default.
• W2285830144 creator A5030260332 @default.
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• W2285830144 date "1992-04-01" @default.
• W2285830144 modified "2023-10-16" @default.
• W2285830144 title "The long protocol of administration of gonadotropin-releasing hormone agonist is superior to the short protocol for ovarian stimulation for in vitro fertilization" @default.
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• W2285830144 doi "https://doi.org/10.1016/s0015-0282(16)54963-2" @default.
• W2285830144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1555692" @default.
• W2285830144 hasPublicationYear "1992" @default.
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