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• W2285862034 endingPage "26" @default.
• W2285862034 startingPage "26" @default.
• W2285862034 abstract "BACKGROUND: There is probably no single way to age. Indeed, so far there is no single accepted explanation or mechanisms of aging (although more than 300 theories have been proposed). There is an overall decline in tissue regenerative potential with age, and the question arises as to whether this is due to the intrinsic aging of stem cells or rather to the impairment of stem cell function in the aged tissue environment.CONTENT: Recent data suggest that we age, in part, because our self-renewing stem cells grow old as a result of heritable intrinsic events, such as DNA damage, as well as extrinsic forces, such as changes in their supporting niches. Mechanisms that suppress the development of cancer, such as senescence and apoptosis, which rely on telomere shortening and the activities of p53 and p16INK4a may also induce an unwanted consequence: a decline in the replicative function of certain stem cells types with advancing age. This decrease regenerative capacity appears to pointing to the stem cell hypothesis of aging.SUMMARY: Recent evidence suggested that we grow old partly because of our stem cells grow old as a result of mechanisms that suppress the development of cancer over a lifetime. We believe that a further, more precise mechanistic understanding of this process will be required before this knowledge can be translated into human anti-aging therapies.KEYWORDS: stem cells, senescence, telomere, DNA damage, epigenetic, aging" @default.
• W2285862034 created "2016-06-24" @default.
• W2285862034 creator A5006688756 @default.
• W2285862034 creator A5051626660 @default.
• W2285862034 date "2010-04-01" @default.
• W2285862034 modified "2023-10-16" @default.
• W2285862034 title "The Stem Cell Hypothesis of Aging" @default.
• W2285862034 cites W122083802 @default.
• W2285862034 cites W1482870101 @default.
• W2285862034 cites W1487552431 @default.
• W2285862034 cites W1658682427 @default.
• W2285862034 cites W1719320996 @default.
• W2285862034 cites W1812816875 @default.
• W2285862034 cites W1844286590 @default.
• W2285862034 cites W190488077 @default.
• W2285862034 cites W1965009601 @default.
• W2285862034 cites W1966453709 @default.
• W2285862034 cites W1966642421 @default.
• W2285862034 cites W1967945897 @default.
• W2285862034 cites W1968695326 @default.
• W2285862034 cites W1970891016 @default.
• W2285862034 cites W1973886069 @default.
• W2285862034 cites W1974481403 @default.
• W2285862034 cites W1976273464 @default.
• W2285862034 cites W1978023490 @default.
• W2285862034 cites W1978658307 @default.
• W2285862034 cites W1978694535 @default.
• W2285862034 cites W1980446548 @default.
• W2285862034 cites W1981108828 @default.
• W2285862034 cites W1981148605 @default.
• W2285862034 cites W1981730769 @default.
• W2285862034 cites W1982647833 @default.
• W2285862034 cites W1983167253 @default.
• W2285862034 cites W1983751803 @default.
• W2285862034 cites W1984187829 @default.
• W2285862034 cites W1985801522 @default.
• W2285862034 cites W1986763150 @default.
• W2285862034 cites W1991210531 @default.
• W2285862034 cites W1991494214 @default.
• W2285862034 cites W1994442675 @default.
• W2285862034 cites W1994917595 @default.
• W2285862034 cites W1997439652 @default.
• W2285862034 cites W1998492363 @default.
• W2285862034 cites W2000212488 @default.
• W2285862034 cites W2000342325 @default.
• W2285862034 cites W2002176403 @default.
• W2285862034 cites W2004273407 @default.
• W2285862034 cites W2006287843 @default.
• W2285862034 cites W2007968891 @default.
• W2285862034 cites W2008380707 @default.
• W2285862034 cites W2009087480 @default.
• W2285862034 cites W2009545124 @default.
• W2285862034 cites W2009948917 @default.
• W2285862034 cites W2011221227 @default.
• W2285862034 cites W2014118496 @default.
• W2285862034 cites W2015094152 @default.
• W2285862034 cites W2015607124 @default.
• W2285862034 cites W2016950157 @default.
• W2285862034 cites W2017303317 @default.
• W2285862034 cites W2017803853 @default.
• W2285862034 cites W2022101330 @default.
• W2285862034 cites W2022572059 @default.
• W2285862034 cites W2023569444 @default.
• W2285862034 cites W2024209230 @default.
• W2285862034 cites W2025843494 @default.
• W2285862034 cites W2027659803 @default.
• W2285862034 cites W2030188161 @default.
• W2285862034 cites W2030817463 @default.
• W2285862034 cites W2032867856 @default.
• W2285862034 cites W2033181526 @default.
• W2285862034 cites W2034962229 @default.
• W2285862034 cites W2035596000 @default.
• W2285862034 cites W2036055444 @default.
• W2285862034 cites W2036676765 @default.
• W2285862034 cites W2037731733 @default.
• W2285862034 cites W2039409357 @default.
• W2285862034 cites W2039463309 @default.
• W2285862034 cites W2039592355 @default.
• W2285862034 cites W2041793728 @default.
• W2285862034 cites W2043671866 @default.
• W2285862034 cites W2044494908 @default.
• W2285862034 cites W2046958356 @default.
• W2285862034 cites W2048376696 @default.
• W2285862034 cites W2049229440 @default.
• W2285862034 cites W2050551830 @default.
• W2285862034 cites W2054059225 @default.
• W2285862034 cites W2057951424 @default.
• W2285862034 cites W2058638257 @default.
• W2285862034 cites W2062538700 @default.
• W2285862034 cites W2063062036 @default.
• W2285862034 cites W2065891752 @default.
• W2285862034 cites W2066733929 @default.
• W2285862034 cites W2067432938 @default.
• W2285862034 cites W2067477189 @default.
• W2285862034 cites W2067593902 @default.
• W2285862034 cites W2071673220 @default.
• W2285862034 cites W2072810104 @default.
• W2285862034 cites W2073429636 @default.

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