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• W2285870394 abstract "In Toxoplasma gondii, an intracellular parasite of humans and other animals, host mitochondrial association (HMA) is driven by a gene family that encodes multiple mitochondrial association factor 1 (MAF1) proteins. However, the importance of MAF1 gene duplication in the evolution of HMA is not understood, nor is the impact of HMA on parasite biology. Here we used within- and between-species comparative analysis to determine that the MAF1 locus is duplicated in T. gondii and its nearest extant relative Hammondia hammondi, but not another close relative, Neospora caninum Using cross-species complementation, we determined that the MAF1 locus harbors multiple distinct paralogs that differ in their ability to mediate HMA, and that only T. gondii and H. hammondi harbor HMA(+) paralogs. Additionally, we found that exogenous expression of an HMA(+) paralog in T. gondii strains that do not normally exhibit HMA provides a competitive advantage over their wild-type counterparts during a mouse infection. These data indicate that HMA likely evolved by neofunctionalization of a duplicate MAF1 copy in the common ancestor of T. gondii and H. hammondi, and that the neofunctionalized gene duplicate is selectively advantageous." @default.
• W2285870394 created "2016-06-24" @default.
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• W2285870394 date "2016-05-01" @default.
• W2285870394 modified "2023-09-27" @default.
• W2285870394 title "Host Mitochondrial Association Evolved in the Human Parasite <i>Toxoplasma gondii</i> via Neofunctionalization of a Gene Duplicate" @default.
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• W2285870394 doi "https://doi.org/10.1534/genetics.115.186270" @default.
• W2285870394 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4858780" @default.
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