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• W2285870519 abstract "Local inflammatory responses and alveolar epithelial cells (AECs) apoptosis are both important for the development of the acute lung injury (ALI), a clinically important complication causing high morbidity and mortality, but little is known about the molecular mechanisms underlying the pathogenesis. Herein, we showed for the first time that expression of Metastasis-associated protein 1 (MTA1), a master transcriptional regulator with the ability to regulate divergent cellular pathways by modifying the acetylation status of crucial target genes, was up-regulated in the alveolar cells of the Escherichia coli lipopolysaccharide (LPS)-induced murine ALI model. Inhibition of MTA1 expression by in vivo siRNA treatment exacerbated the pathology of LPS-induced ALI, by selectively promoting the expression of NF-κB-regulated inflammatory cytokines. Moreover, ablation of MTA1 expression promoted the LPS-induced apoptosis in AEC II cells, leaving AEC I cells unaffected. These data collectively underscore an alveolar facet of this important chromatin modifier, which may represent as a novel regulator and a new therapeutic target for the treatment of ALI." @default.
• W2285870519 created "2016-06-24" @default.
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• W2285870519 date "2016-03-01" @default.
• W2285870519 modified "2023-09-23" @default.
• W2285870519 title "Repression of a chromatin modifier aggravates lipopolysaccharide-induced acute lung injury in mouse" @default.
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• W2285870519 doi "https://doi.org/10.1016/j.bbrc.2016.02.043" @default.
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