Matches in SemOpenAlex for { <https://semopenalex.org/work/W2285874120> ?p ?o ?g. }
- W2285874120 endingPage "7" @default.
- W2285874120 startingPage "1" @default.
- W2285874120 abstract "Reactive oxygen species (ROS) cause damage to macromolecules such as proteins, lipids and DNA and alters their structure and function. When generated outside the cell, ROS can induce damage to anti-proteinases. Anti-proteinases are proteins that are involved in the control and regulation of proteolytic enzymes. The damage caused to anti-proteinase barrier disturbs the proteinase-anti-proteinases balance and uncontrolled proteolysis at the site of injury promotes tissue damage. Studies have shown that ROS damages anti-proteinase shield of the body by inactivating key members such as alpha-2-macroglobulin, alpha-1-antitrypsin. Hypochlorous acid inactivates α-1-antitrypsin by oxidizing a critical reactive methionine residue. Superoxide and hypochlorous acid are physiological inactivators of alpha-2-macroglobulin. The damage to anti-proteinase barrier induced by ROS is a hallmark of diseases such as atherosclerosis, emphysema and rheumatoid arthritis. Thus, understanding the behaviour of ROS-induced damage to anti-proteinases may helps us in development of strategies that could control these inflammatory reactions and diseases." @default.
- W2285874120 created "2016-06-24" @default.
- W2285874120 creator A5000174058 @default.
- W2285874120 creator A5014931462 @default.
- W2285874120 creator A5026066843 @default.
- W2285874120 creator A5042446340 @default.
- W2285874120 creator A5045692447 @default.
- W2285874120 creator A5091868574 @default.
- W2285874120 date "2015-12-23" @default.
- W2285874120 modified "2023-10-03" @default.
- W2285874120 title "Reactive oxygen species and anti-proteinases" @default.
- W2285874120 cites W1174340274 @default.
- W2285874120 cites W1504842322 @default.
- W2285874120 cites W1543429526 @default.
- W2285874120 cites W1552119358 @default.
- W2285874120 cites W1734082729 @default.
- W2285874120 cites W1759706356 @default.
- W2285874120 cites W1826137220 @default.
- W2285874120 cites W1879184430 @default.
- W2285874120 cites W1963750002 @default.
- W2285874120 cites W1968179905 @default.
- W2285874120 cites W1968437147 @default.
- W2285874120 cites W1968471269 @default.
- W2285874120 cites W1972426221 @default.
- W2285874120 cites W1974567109 @default.
- W2285874120 cites W1980734840 @default.
- W2285874120 cites W1982125590 @default.
- W2285874120 cites W1983078193 @default.
- W2285874120 cites W1987074025 @default.
- W2285874120 cites W1990774725 @default.
- W2285874120 cites W1991752585 @default.
- W2285874120 cites W1996180151 @default.
- W2285874120 cites W1999365716 @default.
- W2285874120 cites W2010350321 @default.
- W2285874120 cites W2015591510 @default.
- W2285874120 cites W2015938553 @default.
- W2285874120 cites W2016284627 @default.
- W2285874120 cites W2018978013 @default.
- W2285874120 cites W2020783425 @default.
- W2285874120 cites W2021693564 @default.
- W2285874120 cites W2024066561 @default.
- W2285874120 cites W2024092039 @default.
- W2285874120 cites W2031510175 @default.
- W2285874120 cites W2033857293 @default.
- W2285874120 cites W2048553024 @default.
- W2285874120 cites W2048966030 @default.
- W2285874120 cites W2049784087 @default.
- W2285874120 cites W2053349920 @default.
- W2285874120 cites W2054277474 @default.
- W2285874120 cites W2055574382 @default.
- W2285874120 cites W2058124777 @default.
- W2285874120 cites W2058864001 @default.
- W2285874120 cites W2065076024 @default.
- W2285874120 cites W2066981727 @default.
- W2285874120 cites W2069819117 @default.
- W2285874120 cites W2073703119 @default.
- W2285874120 cites W2076568600 @default.
- W2285874120 cites W2078713790 @default.
- W2285874120 cites W2087593387 @default.
- W2285874120 cites W2091312903 @default.
- W2285874120 cites W2107873069 @default.
- W2285874120 cites W2118127884 @default.
- W2285874120 cites W2118480498 @default.
- W2285874120 cites W2126153472 @default.
- W2285874120 cites W2129137689 @default.
- W2285874120 cites W2135749989 @default.
- W2285874120 cites W2138509775 @default.
- W2285874120 cites W2148167226 @default.
- W2285874120 cites W2148248980 @default.
- W2285874120 cites W2150430599 @default.
- W2285874120 cites W2164613158 @default.
- W2285874120 cites W2170646342 @default.
- W2285874120 cites W22679160 @default.
- W2285874120 cites W4214589643 @default.
- W2285874120 cites W4229630303 @default.
- W2285874120 cites W4235517036 @default.
- W2285874120 cites W4247088117 @default.
- W2285874120 cites W4256538047 @default.
- W2285874120 cites W4379136709 @default.
- W2285874120 doi "https://doi.org/10.3109/13813455.2015.1115525" @default.
- W2285874120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26699123" @default.
- W2285874120 hasPublicationYear "2015" @default.
- W2285874120 type Work @default.
- W2285874120 sameAs 2285874120 @default.
- W2285874120 citedByCount "40" @default.
- W2285874120 countsByYear W22858741202017 @default.
- W2285874120 countsByYear W22858741202018 @default.
- W2285874120 countsByYear W22858741202019 @default.
- W2285874120 countsByYear W22858741202020 @default.
- W2285874120 countsByYear W22858741202021 @default.
- W2285874120 countsByYear W22858741202022 @default.
- W2285874120 countsByYear W22858741202023 @default.
- W2285874120 crossrefType "journal-article" @default.
- W2285874120 hasAuthorship W2285874120A5000174058 @default.
- W2285874120 hasAuthorship W2285874120A5014931462 @default.
- W2285874120 hasAuthorship W2285874120A5026066843 @default.
- W2285874120 hasAuthorship W2285874120A5042446340 @default.
- W2285874120 hasAuthorship W2285874120A5045692447 @default.