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- W2286023442 abstract "Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterised by fatigable voluntary skeletal muscle weakness. The underlying pathogenesis is complex involving adaptive autoimmune responses. Azathioprine remains a first line broad acting immunosuppressant for MG. Due to varied clinical responses to azathioprine we aimed to investigate the relationship between azathioprine metabolites and symptom control. Mild correlations between Quantitative Myasthenia Gravis Score (QMG) vs. 6-thioguanine nucleotides (R = −0.317 p = 0.186) and QMG vs. lymphocyte count (R = 0.402 p = 0.08) were found. Azathioprine metabolite measurement should be considered in MG patients with; pancytopenia, deranged liver function or recurrent infections." @default.
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- W2286023442 date "2016-04-01" @default.
- W2286023442 modified "2023-09-23" @default.
- W2286023442 title "A study of the utility of azathioprine metabolite testing in myasthenia gravis" @default.
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- W2286023442 doi "https://doi.org/10.1016/j.jneuroim.2016.02.015" @default.
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