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• W2286324737 abstract "Over one billion people around the world are affected by presbyopia [1]. A major factor causing presbyopia is stiffening of the crystalline lens. Elasticity, as a material property of the crystalline lens matrix, is often expressed by the Young’s modulus, a unit for stiffness named after Thomas Young. Interestingly, Thomas Young also studied accommodation and developed an instrument to measure objectively the accommodative amplitude. In 1801 he concluded that Bin general, I have reason to think that the faculty diminishes to some degree as persons advance in life^ [2]. This phenomenon has been confirmed in later years by measuring the accommodative amplitude of thousands of subjects, and it was soon suggested that the decline in accommodative amplitude with age should be attributed to stiffening of the crystalline lens [3]. Traditionally, presbyopia is treated with reading spectacles or contact lenses, using bifocal contact lenses or some sort of monovision. More recently, laser refractive surgery has gained popularity as the procedure has options of using multifocality and monovision for treating presbyopia. Another and more invasive alternative is to perform clear lens extraction, in which the natural crystalline lens is replaced by a multifocal or accommodating intraocular lens or a by lens that extends the range of vision. Scleral approaches are also being explored [4]. A less invasive way to combat presbyopia, proposed in 1998 by Myers and Krueger, is to alter the properties of the crystalline lens by photoablation or photodisruption in the crystalline lens by a laser [5]. While mechanical changes in the lens material as a result of laser treatment were already foreseen [6], Krueger and co-workers demonstrated a change in pliability of the lens as a whole, suggesting that presbyopia may be alleviated or reversed [7]. So far, only moderate changes in pliability have been observed. A factor influencing the effect of the procedure is the geometrical pattern inside the lens that is treated by the laser. Studies have concentrated on cutting inside the lens, generating gliding planes along which internal deformations can take place [8]. The search for the optimal gliding planes that maximize lens pliability is the subject of the paper BFinite element modelling of radial lentotomy cuts to improve the accommodation performance of the human lens^ by Burd & Wilde in the current issue of in Graefe’s Archive for Clinical and Experimental Ophthalmology. Instead of experimental studies, e.g. using cadaver eyes, the authors use computational methods to compare the effects of different cutting geometries. Computational methods avoid issues with measurement uncertainties, as well as variance between test specimen and post mortem degradation of cadaver lenses. On the down side, the validity of computational outcomes depends heavily on the validity of the input parameters of the model: geometry, material properties, and boundary conditions. It has been well demonstrated by the same authors in previous studies that the way that the behavior of ocular tissues is modeled has a significant effect on the outcomes [9, 10]. In the current paper the authors demonstrate this once again, by modeling the behavior of the lens matrix in two different ways. First, they model the lens matrix as an incompressible material that is initially linear elastic, but becomes non-linear due to large deformations. This approach of modelling the mechanical behavior of the crystalline lens is most often used in current literature. Then, as an alternative, they introduce a poroelastic material model, which represents the lens matrix as a two-phase mixture of an incompressible fluid and a compressible hyperelastic solid matrix. Whether this is a more realistic * Henk A. Weeber henk.weeber@abbott.com" @default.
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• W2286324737 date "2016-02-18" @default.
• W2286324737 modified "2023-09-23" @default.
• W2286324737 title "Prospects to regain the ability to accommodate" @default.
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• W2286324737 doi "https://doi.org/10.1007/s00417-016-3303-4" @default.
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