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- W2286467982 abstract "Hyperlipidemia is a complex disease that is characterized by increase of triglyceride, cholesterol and low-density lipoprotein (LDL) in serum. Sesamin has been postulated to have an anti-hyperlipidemic effects by lowery cholesterol. In order to evaluate the anti-hyperlipidemic potential of sesamin, it was isolated from stripping sesame oils. For the experiments, 46 patients were divided into two group; one with the hyperlipidemic patients without non-insulin dependent diabetic mellitus (NIDDM), and the other with the hyperlipidemia with NIDDM. The experimental groups received three capsules of sesamin per day for 8 weeks, each containing 2.9 mg sesamin and 2.3 mg alpha-tocopherol in 445 mg wheat germ oil. They were instruced not to change their diet, and habits or alcohol intakes during the experimental period. The total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), and LDL in serum were determined using enzymatic method. The sesamin treatment for 8 weeks in hyperlipidemic patients with NIDDM was effective to reduce TC from 208.6 mg/dl to 198.2 mg/dl and LDL from 122.7 mg/dl to 111.7 mg/dl, respectively. TG and HDL-C were unchanged. On the other hand, C-peptide and insulin levels were incresed, but decreased free amino acid. The GOP or GPT for liver function was not affected by sesamin. The results suggested that sesamin in hyperlipidemic patients with NIDDM decreased serum TC and did not affect the glucose level and liver function. This evidence strongly supports that sesamin in hyperlipidemia patients with NIDDM could reduce serum TC level. Optimum amounts of sesamin to reduce cholesterol level should be further investigated for that prupose." @default.
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- W2286467982 date "1999-01-01" @default.
- W2286467982 modified "2023-09-24" @default.
- W2286467982 title "Hypocholesterolemic effect of sesamin on hyperlipidemia patients with NIDDM" @default.
- W2286467982 hasPublicationYear "1999" @default.
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