FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2286519782> ?p ?o ?g. }

• W2286519782 endingPage "329" @default.
• W2286519782 startingPage "322" @default.
• W2286519782 abstract "For adults with Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in first complete remission (CR1), allogeneic hematopoietic cell transplantation (HCT) is an established curative strategy. However, pediatric-inspired chemotherapy may also offer durable leukemia-free survival in the absence of HCT. We compared 422 HCT recipients aged 18-50 years with Ph-ALL in CR1 reported to the CIBMTR with an age-matched concurrent cohort of 108 Ph- ALL CR1 patients who received a Dana-Farber Consortium pediatric-inspired non-HCT regimen. At 4 years of follow-up, incidence of relapse after HCT was 24% (95% CI 19-28) versus 23% (95% CI 15-32) for the non-HCT (chemo) cohort (P=0.97). Treatment-related mortality (TRM) was higher in the HCT cohort [HCT 37% (95% CI 31-42) versus chemo 6% (95% CI 3-12), P<0.0001]. DFS in the HCT cohort was 40% (95% CI 35-45) versus 71% (95% CI 60-79) for chemo, P<0.0001. Similarly, OS favored chemo [HCT 45% (95% CI 40-50)] versus chemo 73% [(95% CI 63-81), P<0.0001]. In multivariable analysis, the sole factor predictive of shorter OS was the administration of HCT [hazard ratio 3.12 (1.99-4.90), P<0.0001]. For younger adults with Ph- ALL, pediatric-inspired chemotherapy had lower TRM, no increase in relapse, and superior overall survival compared to HCT. Am. J. Hematol. 91:322-329, 2016. © 2015 Wiley Periodicals, Inc." @default.
• W2286519782 created "2016-06-24" @default.
• W2286519782 creator A5001124933 @default.
• W2286519782 creator A5001602966 @default.
• W2286519782 creator A5003947352 @default.
• W2286519782 creator A5008762363 @default.
• W2286519782 creator A5011030256 @default.
• W2286519782 creator A5013398931 @default.
• W2286519782 creator A5016014484 @default.
• W2286519782 creator A5017327825 @default.
• W2286519782 creator A5018065917 @default.
• W2286519782 creator A5018106790 @default.
• W2286519782 creator A5019979915 @default.
• W2286519782 creator A5023700544 @default.
• W2286519782 creator A5026151069 @default.
• W2286519782 creator A5034264716 @default.
• W2286519782 creator A5034779401 @default.
• W2286519782 creator A5035342920 @default.
• W2286519782 creator A5036295405 @default.
• W2286519782 creator A5036654919 @default.
• W2286519782 creator A5041206856 @default.
• W2286519782 creator A5041976525 @default.
• W2286519782 creator A5042915360 @default.
• W2286519782 creator A5042974681 @default.
• W2286519782 creator A5045176208 @default.
• W2286519782 creator A5045583767 @default.
• W2286519782 creator A5047787264 @default.
• W2286519782 creator A5051092535 @default.
• W2286519782 creator A5058862489 @default.
• W2286519782 creator A5062691289 @default.
• W2286519782 creator A5065085606 @default.
• W2286519782 creator A5066224233 @default.
• W2286519782 creator A5066238218 @default.
• W2286519782 creator A5067489954 @default.
• W2286519782 creator A5068050082 @default.
• W2286519782 creator A5069460930 @default.
• W2286519782 creator A5069685528 @default.
• W2286519782 creator A5070043884 @default.
• W2286519782 creator A5070132319 @default.
• W2286519782 creator A5082614208 @default.
• W2286519782 creator A5082924494 @default.
• W2286519782 creator A5084606047 @default.
• W2286519782 creator A5084915025 @default.
• W2286519782 creator A5085167557 @default.
• W2286519782 creator A5085360755 @default.
• W2286519782 creator A5088486180 @default.
• W2286519782 creator A5088647781 @default.
• W2286519782 creator A5088962035 @default.
• W2286519782 creator A5089619585 @default.
• W2286519782 creator A5091222951 @default.
• W2286519782 date "2016-02-22" @default.
• W2286519782 modified "2023-10-15" @default.
• W2286519782 title "Pediatric-inspired therapy compared to allografting for Philadelphia chromosome-negative adult ALL in first complete remission" @default.
• W2286519782 cites W1938211112 @default.
• W2286519782 cites W1971439170 @default.
• W2286519782 cites W1972467214 @default.
• W2286519782 cites W1974981956 @default.
• W2286519782 cites W1975229471 @default.
• W2286519782 cites W1978302657 @default.
• W2286519782 cites W1980791505 @default.
• W2286519782 cites W1981535385 @default.
• W2286519782 cites W1989658067 @default.
• W2286519782 cites W1993312424 @default.
• W2286519782 cites W2007234423 @default.
• W2286519782 cites W2010729137 @default.
• W2286519782 cites W2035343180 @default.
• W2286519782 cites W2043587224 @default.
• W2286519782 cites W2052739233 @default.
• W2286519782 cites W2058128265 @default.
• W2286519782 cites W2072804684 @default.
• W2286519782 cites W2079023050 @default.
• W2286519782 cites W2083825849 @default.
• W2286519782 cites W2085656861 @default.
• W2286519782 cites W2090022119 @default.
• W2286519782 cites W2090845094 @default.
• W2286519782 cites W2091001903 @default.
• W2286519782 cites W2106275447 @default.
• W2286519782 cites W2109285747 @default.
• W2286519782 cites W2109388187 @default.
• W2286519782 cites W2125233997 @default.
• W2286519782 cites W2143775811 @default.
• W2286519782 cites W2146762986 @default.
• W2286519782 cites W2151451975 @default.
• W2286519782 cites W2157051030 @default.
• W2286519782 cites W2157438100 @default.
• W2286519782 cites W4254826799 @default.
• W2286519782 cites W4293241248 @default.
• W2286519782 doi "https://doi.org/10.1002/ajh.24285" @default.
• W2286519782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4764423" @default.
• W2286519782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26701142" @default.
• W2286519782 hasPublicationYear "2016" @default.
• W2286519782 type Work @default.
• W2286519782 sameAs 2286519782 @default.
• W2286519782 citedByCount "69" @default.
• W2286519782 countsByYear W22865197822016 @default.
• W2286519782 countsByYear W22865197822017 @default.
• W2286519782 countsByYear W22865197822018 @default.
• W2286519782 countsByYear W22865197822019 @default.

• next