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- W2286543243 abstract "Background: The hypothesis of a long-term glucose counter-regulation has gained recent interest with the development of continuous glucose monitoring (CGM) technologies, but no long-term studies have been performed. The aim of this study was to evaluate the hypothesis using CGM. Method: Analysis was conducted of insulin treated diabetics’ CGM data. For each patient, hypoglycemic events were identified when blood glucose was 15 minutes and included for those cases where a hypoglycemia-free period existed within 15 hours before and after and where control, free of near-hypoglycemia (blood glucose for 15 minutes) period could be identified at the same time of the day as the hypoglycemia. Blood glucose profiles for each hypoglycemia with near-hypoglycemia-free control were compared. Insulin and carbohydrate intake were also compared. Results: 10 hypoglycemic events in 10 type 1 diabetics were included. No significant difference in blood glucose was seen after hypoglycemia, but insulin intake was 5.7 IU (higher for the first 24 hours after hypoglycemia than in the control period. The carbohydrate intake was 38 g lower after hypoglycemia than in the control periods. Conclusion: The little difference in blood glucose indicates no long-term glucose counter-regulation to hypoglycemia. However, the higher insulin intake and lower carbohydrate intake after hypoglycemia both have hypoglycemic effects, and the blood glucose would therefore Author affiliations: 1 Medical Informatics Group, Department of Health Science and Technology, Aalborg University, Denmark; 2 Department of Endocrinology and Diabetes, Arhus Sygehus, Arhus University Hospital, Denmark _____________________________ Abbreviations: (CGM) continuous glucose sensor, (BMI) body mass index, (HbA1C) hemoglobin A1 _____________________________" @default.
- W2286543243 created "2016-06-24" @default.
- W2286543243 creator A5033850513 @default.
- W2286543243 date "2009-01-01" @default.
- W2286543243 modified "2023-09-26" @default.
- W2286543243 title "Analyzing the long-term glucose counter-regulation to hypoglycemia: methodological approaches" @default.
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- W2286543243 hasPublicationYear "2009" @default.
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