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• W2286563797 startingPage "149" @default.
• W2286563797 abstract "Notch is an evolutionarily conserved signaling pathway that plays a critical role in specifying cell fate and regulating tissue homeostasis and carcinogenesis. Studies using organ cultures and genetically engineered mouse models have demonstrated that Notch signaling regulates prostate development and homeostasis. However, the role of the Notch signaling pathway in prostate cancer remains inconclusive. Many published studies have documented consistent deregulation of major Notch signaling components in human prostate cancer cell lines, mouse models for prostate cancers, and human prostate cancer specimens at both the mRNA and the protein levels. However, functional studies in human cancer cells by modulation of Notch pathway elements suggest both tumor suppressive and oncogenic roles of Notch. These controversies may originate from our inadequate understanding of the regulation of Notch signaling under versatile genetic contexts, and reflect the multifaceted and pleiotropic roles of Notch in regulating different aspects of prostate cancer cell biology, such as proliferation, metastasis, and chemo-resistance. Future comprehensive studies using various mouse models for prostate cancer may help clarify the role of Notch signaling in prostate cancer and provide a solid basis for determining whether and how Notch should be employed as a therapeutic target for prostate cancer." @default.
• W2286563797 created "2016-06-24" @default.
• W2286563797 creator A5006979014 @default.
• W2286563797 creator A5010668623 @default.
• W2286563797 date "2016-02-01" @default.
• W2286563797 modified "2023-09-23" @default.
• W2286563797 title "Notch signaling in prostate cancer: refining a therapeutic opportunity." @default.
• W2286563797 cites W1492874488 @default.
• W2286563797 cites W1518709728 @default.
• W2286563797 cites W1549619413 @default.
• W2286563797 cites W165996924 @default.
• W2286563797 cites W1836846319 @default.
• W2286563797 cites W1887565043 @default.
• W2286563797 cites W1966749136 @default.
• W2286563797 cites W1967826862 @default.
• W2286563797 cites W1972290939 @default.
• W2286563797 cites W1973297092 @default.
• W2286563797 cites W1973569665 @default.
• W2286563797 cites W1977582022 @default.
• W2286563797 cites W1977962361 @default.
• W2286563797 cites W1984365236 @default.
• W2286563797 cites W1986214281 @default.
• W2286563797 cites W1988979297 @default.
• W2286563797 cites W1990490057 @default.
• W2286563797 cites W1993352077 @default.
• W2286563797 cites W1994253118 @default.
• W2286563797 cites W1996470451 @default.
• W2286563797 cites W1996945894 @default.
• W2286563797 cites W1997801717 @default.
• W2286563797 cites W2000589976 @default.
• W2286563797 cites W2001437338 @default.
• W2286563797 cites W2002784005 @default.
• W2286563797 cites W2003219632 @default.
• W2286563797 cites W2005274657 @default.
• W2286563797 cites W2005925039 @default.
• W2286563797 cites W2010057554 @default.
• W2286563797 cites W2018527149 @default.
• W2286563797 cites W2018836208 @default.
• W2286563797 cites W2020579083 @default.
• W2286563797 cites W2030736292 @default.
• W2286563797 cites W2031688735 @default.
• W2286563797 cites W2035220761 @default.
• W2286563797 cites W2044531033 @default.
• W2286563797 cites W2044801274 @default.
• W2286563797 cites W2045089484 @default.
• W2286563797 cites W2046234516 @default.
• W2286563797 cites W2049428525 @default.
• W2286563797 cites W2055359560 @default.
• W2286563797 cites W2059586354 @default.
• W2286563797 cites W2065359040 @default.
• W2286563797 cites W2070081201 @default.
• W2286563797 cites W2076274098 @default.
• W2286563797 cites W2077783560 @default.
• W2286563797 cites W2077893096 @default.
• W2286563797 cites W2080787716 @default.
• W2286563797 cites W2088141769 @default.
• W2286563797 cites W2088578081 @default.
• W2286563797 cites W2088720735 @default.
• W2286563797 cites W2095666604 @default.
• W2286563797 cites W2095904711 @default.
• W2286563797 cites W2100364298 @default.
• W2286563797 cites W2100987153 @default.
• W2286563797 cites W2102767758 @default.
• W2286563797 cites W2109502519 @default.
• W2286563797 cites W2109658769 @default.
• W2286563797 cites W2112126296 @default.
• W2286563797 cites W2113342764 @default.
• W2286563797 cites W2114891019 @default.
• W2286563797 cites W2114913629 @default.
• W2286563797 cites W2115504447 @default.
• W2286563797 cites W2118994129 @default.
• W2286563797 cites W2121302138 @default.
• W2286563797 cites W2121429119 @default.
• W2286563797 cites W2121991468 @default.
• W2286563797 cites W2124958721 @default.
• W2286563797 cites W2133440148 @default.
• W2286563797 cites W2133963006 @default.
• W2286563797 cites W2147598859 @default.
• W2286563797 cites W2148101051 @default.
• W2286563797 cites W2148242912 @default.
• W2286563797 cites W2150245157 @default.
• W2286563797 cites W2151155898 @default.
• W2286563797 cites W2152118417 @default.
• W2286563797 cites W2152302317 @default.
• W2286563797 cites W2153878708 @default.
• W2286563797 cites W2154861644 @default.
• W2286563797 cites W2156978387 @default.
• W2286563797 cites W2159302075 @default.
• W2286563797 cites W2159950734 @default.
• W2286563797 cites W2160127145 @default.
• W2286563797 cites W2160455157 @default.
• W2286563797 cites W2162066500 @default.
• W2286563797 cites W2164942212 @default.
• W2286563797 cites W2171561444 @default.
• W2286563797 cites W58143305 @default.
• W2286563797 doi "https://doi.org/10.14670/hh-11-685" @default.
• W2286563797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4822406" @default.
• W2286563797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26521657" @default.

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