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- W2286616377 abstract "Functional artificial vascular meshes from biodegradable polymers have been widely explored for certain tissue engineered meshes. Still, the foreign body reaction and limitation in endothelialization are challenges for such devices. Here, degradable meshes from phase-segregated multiblock copolymers consisting of poly(ε-caprolactone) (PCL) and polydepsipeptide segments are successfully prepared by electrospinning and electrospraying techniques. The pEGFP-ZNF580 plasmid microparticles (MPs-pZNF580) were loaded into the electrospun meshes to enhance endothelialization. These functional meshes were evaluated in vitro and in vivo. The adhesion and proliferation of endothelial cells on the meshes were enhanced in loaded mesh groups. Moreover, the hemocompatibility and the tissue response of the meshes were further tested. The complete tests showed that the vascular meshes modified with MPs-pZNF580 possessed satisfactory performance with an average fiber diameter of 550 ± 160 nm, tensile strength of 27 ± 3 MPa, Young’s modulus of 1. 9 ± 0.2 MPa, water contact angle of 95° ± 2°, relative cell number of 122% ± 1% after 7 days of culture, and low blood platelet adhesion as well as weak inflammatory reactions compared to control groups." @default.
- W2286616377 created "2016-06-24" @default.
- W2286616377 creator A5009932563 @default.
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- W2286616377 creator A5065971725 @default.
- W2286616377 date "2016-02-23" @default.
- W2286616377 modified "2023-10-16" @default.
- W2286616377 title "Evaluation of Electrospun PCL-PIBMD Meshes Modified with Plasmid Complexes in Vitro and in Vivo" @default.
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- W2286616377 doi "https://doi.org/10.3390/polym8030058" @default.
- W2286616377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6432533" @default.
- W2286616377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30979153" @default.
- W2286616377 hasPublicationYear "2016" @default.
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