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- W2286681806 abstract "In animal cell culture aurintricarboxylic acid (ATA) effects on antiaggregation, anti-apoptosis, and it acts insulin-like growth factor under serum free condition. ATA is used in biological experiments as a protein synthesis inhibitor. In the meantime, we found another function of ATA that it can decrease antibody production titer in serum free condition. Addition and deletion of ATA experiments showed that it is important component in antibody production inhibition. We processed with two different medium, PF CHO MPS (Hyclone, commercial medium) and Protein free medium (In-house medium) and it showed similar results that antibody production titer decreased in ATA contained condition from 40~50 mg/L to below 10 mg/L.In short, ATA can be an antibody production inhibitor in some specific serum free condition." @default.
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- W2286681806 date "2011-04-01" @default.
- W2286681806 modified "2023-09-24" @default.
- W2286681806 title "Aurintricarboxylic Acid Inhibits Antibody Production in CHO Cell Culture under Serum Free Condition" @default.
- W2286681806 hasPublicationYear "2011" @default.
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